Literature on Oral Mucositis and Cancer Therapies
 
Chemotherapy- and/or radiation therapy-induced mucositis Chemotherapy- and/or radiation therapy-induced mucosits literature for the dental professional Treatments for chemotherapy- and/or radiation therapy-induced mucositis
Chemotherapy- and/or radiation therapy-induced mucositis
Radiation induced oral mucositis
Kumar et al.
2010, Indian Journal of Palliative Care
The present day management of oral mucositis is mostly palliative and or supportive care. The newer guidelines are suggesting Palifermin, which is the first active mucositis drug as well as Amifostine, for radiation protection and cryotherapy. The current management should focus more on palliative measures, such as pain management, nutritional support, and maintenance, of good oral hygiene.
 
Current trends in the management of oral mucositis related to cancer treatment
Biswal
2008, Malaysian Journal of Medical Sciences
Article discusses methods for the prevention and treatment of oral mucositis including: multi-targeted treatment supplemented by aggressive oral hygiene, reactive oxygen species inhibitors, growth factors and use of specific topical agents to improve treatment of the condition in the future.
 
Oral mucositis-related morbidity and resource utilization in a prospective study of head and neck cancer patients
Isitt et al.

2007, The Journal of Supportive Oncology
Research examined the burden of oropharyngeal mucositis and its downstream resource consumption and risk of complications in head and neck cancer patients receiving radiation with or without chemotherapy.
 
Updated clinical practice guidelines for the prevention and treatment of mucositis
Keefe et al.
2007, Cancer
Article discusses the recommendations of a panel of experts on clinical practice guidelines for the prevention and treatment of mucositis.
 
Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy
Murphy
2007, The Journal of Supportive Oncology
Article discusses the clinical and economic consequences of chemotherapy and/or radiation induced mucositis and recommends that effective treatments are needed to decrease function loss, minimize symptom burden, and lower treatment costs.
 
Consequences of mucositis-induced treatment breaks and dose reductions on head and neck cancer treatment outcomes
Rosenthal
2007, The Journal of Supportive Oncology
Article discusses the consequences of treatment breaks for cancer patients with chemotherapy and/or radiation induced mucositis. Effective prophylaxis or treatment could reduce the probability of treatment breaks and dose reductions and thus improve outcomes.
 
Diagnosis and management of oral mucositis
Silverman
2007, The Journal of Supportive Oncology
This article summarizes the impact of oral mucositis in patients with cancer, including its pathogenesis, diagnosis, financial implications, and management.
 
Cancer treatment-induced mucositis pain: strategies for assessment and management
Harris
2006, Therapeutics and Clinical Risk Management
Article presents an assessment tool specific to mucositis pain, including physical, functional, and pain parameters.
 
New strategies for management of oral mucositis in cancer patients
Peterson
2006, The Journal of Supportive Oncology
Article discusses the guidelines put forth by the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology for treating oral mucositis in cancer patients and new therapies to complement the traditional treatment and prevention guidelines.
 
Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis (abstract)
Rubenstein et al.
2004, Cancer
Article discusses the evidenced-based guidelines developed from a comprehensive literature review for preventing, evaluating, and treating cancer therapy-induced oral/GI mucositis.
 
Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2: Diagnosis and management of mucositis
Scully et al.
2004, Head & Neck
Article reviews publications on the diagnosis and management of oral mucositis accessible from a MEDLINE search using as key words mucositis, radiotherapy, chemotherapy, hemopoietic stem cell transplant and oral.
 
Mechanisms for radiation-induced oral mucositis and the consequences (abstract)
Shih et al.
2003, Cancer Nursing
Paper describes the mechanisms, risk factors, prevalence, and magnitude of radiation therapy-related oral mucositis and its morbidities in patients with head and neck cancer.
 
Oral mucositis complicating chemotherapy and/or radiotherapy: Options for prevention and treatment
Kostler et al.
2001, CA A Cancer Journal for Clinicians
Article discusses the pathogenesis and treatment of oral mucositis.
 
Chemotherapy- and/or radiation therapy-induced oral mucositis literature for the dental professional
Management of oral mucositis in patients with cancer
Lalla et al.
2008, Dental Clinics of North America
Article discusses the epidemiology, clinical significance, economic impact, pathogenesis, clinical course, clinical management, and future directions in research of oral mucositis.
 
Effects of oral care on development of oral mucositis and microorganisms in patients with esophageal cancer
Yoneda et al.
2007, Japanese Journal of Infectious Disease
Researchers evaluated the effects of special oral care using a toothbrush with combined irrigation and suctioning function, along with povidone-iodine to treat oral bacteria and mucositis, in esophageal cancer patients undergoing chemoradiotherapy.
 
Preventive intervention possibilities in radiotherapy-and chemotherapy-induced oral mucositis: Results of meta-analysis
Stokman et al.
2006, Journal of Dental Research
The aim of this meta-analyses was to evaluate the effectiveness of interventions for the prevention of oral mucositis in cancer patients treated with head and neck radiotherapy and/or chemotherapy, with a focus on randomized clinical trials.
 
Interventions for preventing oral mucositis for patients with cancer receiving treatment
Worthington et al.
2006, Cochrane Database of Systematic Reviews
The objective of this review is to evaluate the effectiveness of prophylactic agents for oral mucositis in patients with cancer receiving treatment, compared with other potentially active interventions, placebo or no treatment.
 
Cancer therapy-related oral mucositis
Redding
2005, Journal of Dental Education
Article discusses the process of cancer therapy-related oral mucositis and its effects on the oral cavity.
 
Prevention of oral mucositis and oral candidiasis for patients with cancer treated with chemotherapy: Cochrane Systematic Review
Worthington and Clarkson
2002, Journal of Dental Education
The objective of this study was to determine whether oral prophylactic agents are superior to placebo or no treatment on the incidence of oral mucositis and oral candidiasis for patients with cancer. There is weak and unreliable evidence that ice chips prevent mucositis. There is evidence that prophylactic use of antifungal agents, which are absorbed or partially absorbed from the gastrointestinal tract, reduce the clinical signs of oral candidiasis.
 
Treatments for chemotherapy- and/or radiation therapy-induced mucositis
 Palifermin for management of treatment-induced oral mucositis in cancer patients
Barash et al.
2009, Biologics
Article evaluates the pre-clinical and clinical evidence and discusses the clinical applications of keratinosyte growth factor as an adjunct therapeutic agent in oncology.
 
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis
Chung et al.
2009, Carcinogenesis
Study investigated whether epigenetic therapy with a histone deacetylase inhibitor has dual benefits for radiation-induced oral mucositis and chemical-induced oral carcinogenesis.
 
A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: a second analysis
Jham et al.
2009, Journal of Oral Science
The aim of this study was to determine the impact of bethanechol administration concomitant to radiotherapy on oral mucositis, candidiasis and taste loss. Bethanechol does not appear to reduce the incidence of mucositis, candidiasis, and taste loss when administered during radiotherapy.
 
Phase II, randomized, double-blind, placebo-controlled study of recombinant human intestinal trefoil factor oral spray for prevention of oral mucositis in patients with colorectal cancer who are receiving fluorouracil-based chemotherapy
Peterson et al.
2009, Journal of Clinical Oncology
Study evaluated the safety and efficacy of recombinant human intestinal trefoil factor administered as topical oral spray for prevention and treatment of chemotherapy-induced oral mucositis.
 
The effect of three mouthwashes on radiation-induced oral mucositis in patient with head and neck malignancies: A randomized control trial
Kumar et al.
2008, Journal of Cancer Research and Therapeutics
The aim of this study was to assess the effect of three alcohol-free mouthwashes on radiation-induced oral mucositis in patients with head and neck malignancies.
 
Low energy laser in prevention of oral mucositis in patients receiving radiotherapy and/or chemotherapy in Pernambuco Cancer Hospital
Kelner and de Castro
2007, Applied Cancer Research
Study evaluated the benefits of low intensity laser and 0.12% chlorohexidine gluconate in the prevention of oral mucositis induced by radiation, associated or not with chemotherapy, and considered degrees/severity, time of appearance of the lesions and functional loss.
 
Reduced incidence and severity of acute radiation mucositis by WF10 (IMMUNOKINE) as adjunct to standard of cure in the management of head & neck cancer patients
Penpattanagul
2007, Journal of the Medical Association of Thailand
Study evaluated the role of WF10-immunotherapy in reducing oropharyngeal complications in head and neck cancer chemotherapy.
 
Administration of Ratanhia-based herbal oral care products for the prophylaxis of oral mucositis in cancer chemotherapy patients: a clinical trial
Tiemann et al.
2007, Evidenced-based Complementary and Alternative Medicine
Study demonstrated preventive and therapeutic effects of dental treatment and regular use of Weleda Ratanhia-Mundwasser (herbal mouthwash) and Weleda Pflansen-Zahngel (herbal tooth-gel) on oral mucositis during chemotherapy.
 
Oral doxepin rinse: The analgesic effect and duration of pain reduction in patients with oral mucositis due to cancer therapy
Epstein et al.
2006, Anesthesia and Analgesia
Research assessed pain reduction after topical doxepin rinse in patients with oral mucositis resulting from cancer and cancer therapy.
 
Effect of low level helium-neon (He-Ne) laser therapy in the prevention & treatment of radiation induced mucositis in head & neck cancer patients
Maiya et al.
2006, Indiana Journal of Medical Research
Research aimed to find out the effect of low-level helium –neon (He-Ne) laser in the prevention and treatment of radiation induced mucositis in head and neck cancer patients.
 
Randomized phase II study of GM-CSF to reduce mucositis caused by accelerated radiotherapy of laryngeal cancer
McAleese et al.
2006, The British Journal of Radiology
The study assessed the effect of subcutaneous molgramostin (granulocyte-macrophage colony stimulating factor; GM-CSF) injections on acute radiation morbidity in patients undergoing accelerated radiotherapy for laryngeal cancer.
 
Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy
Rosen et al.
2006, Journal of Clinical Oncology
Study aimed to characterize the efficacy and safety of palifermin in reducing the incidence of oral mucositis and diarrhea when administered to patients with metastatic colorectal cancer receiving fluorouracil/leucovorin chemotherapy.
 
Patients with moderate chemotherapy-induced mucositis: pain therapy using low intensity lasers (abstract)  
Nes and Posso
2005, International Nursing Review
The objective of this research was to verify the analgesic effect of low level laser therapy on patients with moderate chemotherapy-induced oral mucositis, when measured immediately after each laser application.