Literature on Osteonecrosis of the Jaw and Cancer
Therapies
 
Bisphosphonate Osteonecrosis of the Jaw     Osteoradionecrosis of the Jaw        
     
Bisphosphonate Osternecrosis of the Jaw
     
The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: A south Australian case series (abstract)
Goss et al.
2010, Journal of Oral and Maxillofacial Surgery
The purpose of this study was to determine the number of bisphosphonate-associated cases of dental implant failure in South Australia.
 
Bone: Cancer cohort study confirms dental risk factors for bisphosphonate-related ONJ (abstract)
Heath
2010, Nature Reviews Endocrinology
The investigators enrolled 1,621 patients with malignant disease who had received monthly intravenous bisphosphonates for a minimum of 5 months at a single center in Greece between January 2000 and October 2008. All participants were asked to attend a comprehensive dental examination and review of their dental history. The main outcome measure was development of ONJ during the follow-up period.
 
Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats (abstract)
Hokugo et al.
2010, Journal of Bone and Mineral Research
The objective of this study was to establish an animal model of bisphosphonate-related ONJ by testing the combination of these risk factors.
 
Bisphosphonate-related osteonecrosis of the jaw: Tip of the iceberg (abstract)
Knight et al.
2010, Journal of Craniofacial Surgery
In this paper, the authors explore historical parallels and provide the most comprehensive review to date in the literature about the presentation, diagnosis, treatment, pathophysiology, oncogenic associations, and best practice guidelines. Legal action pursuant to bisphosphonate-related osteonecrosis of the jaw is underway on 3 continents, and we believe that every health care professional should become au fait with this condition for which our growing case series represents merely the tip of the iceberg.
 
Tooth extraction in patients taking intravenous bisphosphonates: A preventive protocol and case series
Lodi et al.
2010, Journal of Oral and Maxillofacial Surgery
The purpose of this study was to test the efficacy of a protocol in preventing the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after tooth extraction.
 
Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with antiangiogenic agents
Aragon-Ching et al.
2009, Cancer Investigation
Authors report a higher than usual incidence of ONJ, 11 of 60 (18.3%, 95% Confidence Interval, CI: 9% – 28%) patients enrolled in a phase II clinical trial combining bevacizumab, docetaxel, thalidomide, and prednisone (ATTP) in chemotherapy-naïve men with metastatic castration resistant prostate cancer (mCRPC).
 
Bisphosphonate-related osteonecrosis of the jaw in cancer patients and hyperbaric oxygen therapy
Erkan et al.
2009, Journal of the Pancreas (Online)
Letter comments on the findings of Smith et al. and discusses hyperbaric oxygen therapy for the treatment of bisphosphonate-related osteonecrosis of the jaw.
 
Epidemiologic studies are needed to clarify whether dental modalities could be predictors for bisphosphonate osteonecrosis of the jaw in breast cancer patients
Kyrgidis and Andreadis
2009, The Oncologist
Authors suggest that further epidemiologic studies are need to clarify the potential role of dental modalities in osteonecrosis of the jaw development.
 
Decreased occurrence of osteonecrosis of the jar after implementation of dental preventive measures in solid tumor patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan
Ripamoni et al.
2009, Annals of Oncology
Study investigated the occurrence of ONJ before and after implementation of dental preventive measures when starting BP therapy.
 
Oral osteonecrosis associated with the use of zoledronic acid: First case of a patient with advanced pancreatic cancer and bone metastases
Smith et al.
2009, Journal of the Pancreas (Online)
Letter discusses a case report of a man with pancreatic cancer and bone metastases diagnosed with oral osteonecrosis of the jaw.
 
Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients
Walter et al.
2009, Acta Stomatologica Croatica
The objective of this study was to evaluate the prevalence of bisphosphonate-associated-osteonecrosis-of-the-jaws (BP-ONJ) and protective factors of BP-ONJ-development in breast cancer patients with osseous metastasis and bisphosphonate therapy using systematical dental oral examinations.
 
 FrequeFrequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates
Hoff et al.
2008, Journal of Bone and Mineral Research
Authors conducted a retrospective analysis of 4019 patients treated with intravenous bisphosphonates between 1996 and 2004. Our goals were to estimate the frequency, understand the clinical presentation, and identify risk factors associated with ONJ development.
 
Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American society for bone and mineral research (abstract)
Khosla et al.
2007, Journal of Bone and Mineral Research
ONJ has been increasingly suspected to be a potential complication of bisphosphonate therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder. This report summarizes the findings and recommendations of the task force.
 
Osteonecrosis of the jaw in cancer patients receiving IV bisphosphonates
Poznak
2006, Oncology
Author reviews available data on osteonecrosis of the jaw.
 
Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer
Ruggiero et al.
2006, Journal of Oncology Practice
This article discusses osteonecrosis of the jaw (ONJ) and offers health care professionals practical guidelines and recommendations for the prevention, diagnosis, and management of ONJ in cancer patients receiving bisphosphonate treatment.
 
Systematic review: Bisphosphonates and osteonecrosis of the jaws
Woo et al.
2006, Annals of Internal Medicine
Authors briefly review the action of bisphosphonates, outline the clinical manifestations of bisphosphonate- associated osteonecrosis of the jaws, summarize current treatment strategies, discuss possible mechanisms of etiopathogenesis, and suggest avenues of research.
 
Osteonecrosis of the jaw and bisphosphonates
Durie et al.
2005, The New England Journal of Medicine
Letter to the editor of The New England Journal of Medicine discussing osteonecrosis of the jaw and bisphosphonates.
 
Bisphosphonate-associated osteonecrosis of the jaws: A review of current knowledge
Markiewicz et al.
2005, Journal of the American Dental Association
Article describes a case of osteonecrosis of the jaws in a patient receiving long-term bisphosphonate therapy for cancer. The authors offer recommendations for management and prevention of oral complications.
 
Managing the care of patients with bisphosphonate-associated osteonecrosis: An American Academy of Oral Medicine position paper
Migliorati et al.
2005, The Journal of the American Dental Association
This position paper addresses the prevention of bisphosphonate-associated osteonecrosis (BON) and the management of care of patients with cancer and/or osteoporosis who are receiving bisphosphonates and who have BON or are at risk of developing it.
 
Osteoradionecrosis of the jaw
 
OsteoradioneOsteoradionecrosis of the jaws-a current overview-part 1: Physiopathology and risk and predisposing factors (abstract)
Chrcanovic et al.
2010, Oral and Maxillofacial Surgery
The aim of this paper is to explore the current theories about definition, classification, incidence and physiopathology of osteoradionecrosis (ORN) of the jaws. Moreover, it is discussed the predisposing and risk factors for the development of osteoradionecrosis based on the literature review.
 
Effectiveness of hyperbaric oxygen therapy in mandibular osteoradionecrosis shown by thermography monitoring (abstract)
Jedruski-Pawlowska et al.
2010, Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
The purpose of this study was to assess thermographic records of ORN patients in different stages of hyperbaric oxygen therapy.
 
Lack of osteoradionecrosis of the mandible after IMRT for head and neck cancer: Likely contributions of both dental care and improved dose distribution
Ben-David et al.
2007, International Journal of Radiation Oncology *Biology* Physics
The purpose of this study was to assess the prevalence and the dosimetric and clinical predictors of mandibular osteoradionecrosis (ORN) in patients with head and neck (HN) cancer who underwent pre-therapy dental evaluation and prophylactic treatment according to a uniform policy and were treated with intensity modulated radiation therapy (IMRT).