Frank Lippert, MSc, PhD

Frank Lippert, MSc, PhD
Frank Lippert, MSc, PhD

Assistant Research Professor
Director, Remineralization Research Program

Contact Info

Phone  (317) 274-3983
Fax       (317) 274-5425

Office Address

Indiana University School of Dentistry 
Oral Health Research Institute 
415 Lansing St., Indianapolis, IN 46202-2876


Frank Lippert, MSc, PhD, holds the position of Assistant Research Professor in the Department of Preventative and Community Dentistry at the Indiana University School of Dentistry (IUSD) which he joined in 2009. Dr. Lippert directs the OHRI Remineralization Research Program. He is originally from Germany where he studied food science at the Technical University of Dresden. Dr. Lippert received his PhD from the Dental School of the University of Bristol, UK in 2004 and then joined the Aquafresh New Product Research group at GlaxoSmithKline in Weybridge, UK. His research activities in dentistry started as a postgraduate student in 2000, when he was conducting dental erosion research using atomic force microscopy and nanoindentation in vitro as well as in situ, leading to several publications in peer-reviewed journals. Dr. Lippert continued his research activities at GlaxoSmithKline where he was directly involved in the development of oral healthcare products with improved fluoride and anti-caries effectiveness by investigating the impact of formulation excipients on fluoride delivery combined with the development of in vitro models with better in vivo/in situ predictiveness. He was also actively engaged in abrasion research, investigating the impact of abrasives and toothbrushes on dentine and enamel abrasivity, stain removal and enamel surface finish, with the aim to develop systems with improved cleaning and smoothening while reducing abrasivity. Dr. Lippert has an extensive knowledge of dentifrice and mouthrinse formulation science, combined with a strong background in tooth wear and caries research.


Dr. Lippert directs the Remineralization Unit which is an integral part of the Laboratory Testing Facility at the Oral Health Research Institute.

Research Interests

Dr. Lippert conducts hard tissue caries research and predominantly focuses on the following areas:

  • investigation of the mineral distribution of artificial and natural caries/white spot lesions
  • understanding the impact of mineral distribution on lesion progression and remineralization
  • investigation of the efficacy of novel anti-caries agents
  • developing a thorough understanding of the role of fluoride in the caries process with particular emphasis on fluoride's response to lesions with different mineral distributions

Dr. Lippert is also active in dental erosion/abrasion research in collaboration with the program director Dr. Hara.


Lippert F, Hara AT. Strontium and caries: a long and complicated relationship. Caries Res accepted for publication.

Lippert F, Butler A, Lynch RJM. Characteristics of methylcellulose acid gel lesions created in human and bovine enamel. Caries Res accepted for publication.

Lippert F. The effects of lesion baseline characteristics and different Sr:Ca ratios in plaque fluid-like solutions on caries lesion de- and remineralization. Arch Oral Biol accepted for publication.

Lippert F, Hara AT. Fluoride dose-response of human and bovine enamel caries lesions under remineralizing conditions. Amer J Dent accepted for publication.

Lippert F, Martinez-Mier EA, Soto-Rojas AE. Effects of Fluoride Concentration and Temperature of Milk on Caries Lesion Rehardening. J Dent 2012; 40:810-3.

Yassen GH, Lippert F, Eckert GJ, Eder JSO, Ferreira Zandona A.The effect of strontium and combinations of strontium and fluoride on the remineralization of artificial caries lesions in vitro. Quintessence Int 2012;43:e95–e103..

Lippert F. Dose-Response Effects of Zinc and Fluoride on Caries Lesion Remineralization. Caries Res 2012;46:62-68.

Lippert F, Butler A, Lynch RJM, Hara AT. Effect of Fluoride, Lesion Baseline Severity and Mineral Distribution on Lesion Progression. Caries Res 2012;46:23-30.

Churchley D, Lynch RJM, Lippert F, Eder JSO, Alton J, Gonzalez-Cabezas C. Terahertz Pulsed Imaging Study to Assess Remineralization of Artificial Caries Lesions. J Biomed Opt 2011;16:article 026001.

Lippert F, Butler A, Lynch RJM. Enamel Demineralization and Remineralization under Plaque Fluid-Like Conditions: A Quantitative Light-Induced Fluorescence Study. Caries Res 2011;45:155-61.

Lippert F, Lynch RJM, Eckert GJ, Kelly SA, Hara AT, Zero DT. In Situ Fluoride Response of Caries Lesions with Different Mineral Distributions at Baseline. Caries Res 2011;45:47-55.

Laurance-Young P, Bozec L, Gracia L, Rees R, Lippert F, Lynch RJM, Knowles JC. A review of the structure of human and bovine dental hard tissues and their physicochemical behaviour in relation to erosive challenge and remineralisation. J Dent 2011;39:266-72.

Lippert F, Zero DT, Tenuta LMA. Letter to the Editor. J Dent Res 2011;90:5.

Lippert F, Newby EE, Lynch RJM, Chauhan VK, Schemehorn BR. Laboratory Assessment of the Anticaries Potential of a New Dentifrice. J Clin Dent. 2009;20(2):45-49.

Lippert F, Parker DM, Jandt KD. Susceptibility of deciduous and permanent enamel to dietary acid-induced erosion studied with atomic force microscopy nanoindentation. Eur J Oral Sci. 2004;112(1):61-6.

Lippert F, Parker DM, Jandt KD. In vitro demineralization/remineralization cycles at human tooth enamel surfaces investigated by AFM and nanoindentation. J Colloid Interface Sci. 2004;280(2):442-8.

Lippert F, Parker DM, Jandt KD. In situ remineralisation of surface softened human enamel studied with AFM nanoindentation. Surf Sci. 2004;553(1-3):105-14.

Lippert F, Parker DM, Jandt KD. Toothbrush abrasion of surface softened enamel studied with tapping mode AFM and AFM nanoindentation. Caries Res. 2004;38(5):464-72.