Sean (Shih-Yao) Liu, DDS, MS, PhD

Sean (Shih-Yao) Liu, DDS, MS, PhD
Sean (Shih-Yao) Liu, DDS, MS, PhD

Assistant Professor of Orthodontics
Director, Mineralized Tissues and Histology Research Lab
Director, Orthodontic Fellowship Program


Contact Info

Phone 317-274-3345
Fax 317-278-1438

Office Address

Indiana University School of Dentistry
Department of Orthodontics and Oral Facial Genetics
1121 West Michigan Street, DS 250A
Indianapolis, IN 46202


Background
Dr. Sean (Shih-Yao) Liu joined the department in November 2008. Originally, from Taiwan, Dr. Liu earned his DDS (1999) and MS in Orthodontics (2003) at Taipei Medical University. He went on to pursue a PhD (2008) in Biomedical Sciences at Baylor College of Dentistry. Dr. Liu’s main thrust in research is on sutural expansion and their reaction to force. At IU, Dr. Liu is primarily charged with maintaining an active research program and teaching the didactic component of G927 – Research in Orthodontics. Dr. Liu is a member of the International Association for Dental Research, American Association for Dental Research, and American Association of Orthodontists.

Professional Societies
American Association of Orthodontists
International Association for Dental Research
American Association for Dental Research
Indiana Section of the American Association for Dental Research
Taiwan Association of Orthodontists
Taiwan Association for Dental Science



Journal Reviewer
Reviewer, American Journal of Orthodontics & Dentofacial Orhtopedics Publications

Awarded Grants and Fellowships

Amphibian Limb Regeneration and Cell Cycle Regeneration Multidisciplinary Undergraduate Research Institute (MURI), IUPUI  $7,800 10/05/2012-12/13/2013  Role: Mentor (PI: Song)   

                  

Development of a model for the midpalatal maxillary expansion 07/01/2012-07/15/2012 Borroughs Welcome Fund  $5,180CA  Role: Mentor/Co-investigator (PI: Romanyk)

 

Center for three-dimensional imaging of the craniofacialdental complex 07/01/2011-06/30/2014 IUPUI Signature Centers Initiative $300,000 Role: Co-investigator (PI: Kula)     

     

Comparison of orthodontic treatment strategies $1,264,976 04/01/2009-06/30/2013 R01, NIDCR Role Co-Investigator (PI: Chen)

 

Role of periostin in bone remodeling during orthodontic tooth movement  IUSD Post-Doctoral Research Award Program 10/01/2010-12/16/2012 $85,428 Role: PI& Mentor (Post-doctoral Fellow: Sun)

 

The effects of systemic fluoride intake on orthodontically induced inflammatory root resorption in DBA/2J mice Delta Dental Master Thesis Program, Delta Dental Foundation $3,000                             05/06/2011-06/30/2012 Role: PI &Mentor (Student: Fanning)

 

Initial rotational tendency experienced by a lateral incisor during space closure using different ligation methods on different archwires IUSD student research fellowships 07/01/2011-06/30/2012    $3,500 Role: Co-Investigator (Mentor: Chen; Student: Wu)     

               

Implant/titanium testing  Hebrew University of Jerusalem 12/01/2009-12/31/2011 $14,750 Role: Lab director (contract work)

 

A novel 3D superimposing technology to evaluate the mandibular growth  07/01/2010-06/30/2011     
Orthodontic Faculty Development Award, American Association of Orthodontists Foundation
$15,000 Role: PI

 

Effects of fluoride on condylar growth and density during lateral functional shift of the mandible IUSD Student Research Fellowships  08/15/2010-08/15/2011 $5,000 Role: Co-Mentor (Co-Mentor: Stewart; Student: Elsahy)

 

Quantitative study of repair in segmental defects of the limb and mandibular bones of the Axolotl Research Support Fund Grant (RSFG), IUPUI 04/01/2010-03/31/2011 $22,800  Role: Co-Investigator (PI: Song)

A novel approach to stimulate mandibular growth 03/01/2010-02/28/2011 Research Support Fund Grant (RSFG), Indiana University-Purdue University Indianapolis (IUPUI) $54,760 Role: PI

Osteoblast Differentiation and Mineralization on Stainless Steel and Titanium-Alloy Mini Implant Screws Multidisciplinary Undergraduate Research Institute (MURI), IUPUI $1,968                             06/01/2010-12/13/2010 Role: Mentor and co-investigator (PI: Bruzzaniti)                                                                                                                                                                                                                  

Role of periostin in bone remodeling during orthodontic tooth movement Indiana University School of Dentistry professional development program $6,000 06/01/2009-06/30/2010 Role: PI

Awards and Honors

TEACHING

Albert P. Westfall Memorial Teaching Fellowship Award - American Association of Orthodontists 

06/2010

Faculty First Award -American Association of Orthodontists 09/2009                                                                           

RESEARCH

Beni Solow Award -European Orthodontic Society
06/2011

Dentsply International Student Clinician Award - American Dental Association (Awardee: Jaclyn Ponder; Role: mentor)                                                                                           
04/2011

Outstanding Research Award-Congress of Taiwan Association of Orthodontics
05/2003

GENERAL

Best Graduate Resident - Taipei Medical University Hospital                                           
08/2003

Publications

Refereed

Liu Y, Song F, Sun J, Yu H, Liu SS. Suture compression induced bone resorption with intensified MMP-1 and 13 expressions. Bone. 2012 Jul 18. [Epub ahead of print]

Smith, T., Ghoneima A.; Stewart K.; Liu, S., Eckert G., Halum S.; & Kula K. (2012). Three-dimensional computed tomography analysis of airway volume changes following rapid maxillary expansion. Am J Orthod Dentofacial Orthop. 141(5):618-26.

Smith, B., Stewart, K. Liu, S.S., Eckert, G., & Kula, K. Prediction of orthodontic treatment of surgically exposed unilateral maxillary impacted canine cases. Angle Orthod. 2011 Dec 9. [Epub ahead of print]

Larrabee, T., Liu S. S., Soto, A., Torres-Gorena, A., Eckert, G.,  Stewart, K. The effects of varying alcohol concentrations commonly found in mouth rinses on the force decay of elastomeric chain. Angle Orthod. 2012 Feb 6. [Epub ahead of print]

Yadav, S., Upadhyay, M., Liu, S., Roberts, E., Neace, W.P., & Nanda, R. (2012). Microdamage of the cortical bone during mini-implant insertion with self-drilling and self-tapping techniques: a randomized controlled trial. Am J Orthod Dentofacial Orthop, 141(5):538-46.

Liu, S. S., & Buschang, P. H. (2011). How does tooth eruption relate to vertical mandibular growth displacement? Am J Orthod Dentofacial Orthop, 139(6), 745-751.

Liu, S. S., Opperman, L. A., Kyung, H. M., & Buschang, P. H. (2011). Is there an optimal force level for sutural expansion? Am J Orthod Dentofacial Orthop, 139(4), 446-455.

Liu, S. S., Kyung, H. M., & Buschang, P. H. (2010). Continuous forces are more effective than intermittent forces in expanding sutures. Eur J Orthod, 32(4), 371-380.

Liu, S. S., Opperman, L. A., & Buschang, P. H. (2009). Effects of recombinant human bone morphogenetic protein-2 on midsagittal sutural bone formation during expansion. Am J Orthod Dentofacial Orthop, 136(6), 768 e761-768; discussion 768-769.

Buschang, P. H., Carrillo, R., Liu, S. S., & Demirjian, A. (2008). Maxillary and mandibular dentoalveolar heights of French-Canadians 10 to 15 years of age. Angle Orthod, 78(1), 70-76.

Liu, S. (2003). GH/IGF axis in bone formation during Orthodontic Treatment: Literature Review and Possibility in the Future. J Taiwan Assoc Orthod. 15(1):23-26.

Liu, S.. Su, B., Chang, C.Y., & Tsai, C.Y. (2004). Serum changes of the growth hormone/insulin-like growth factor axis during initial orthodontic treatment. Chinese Dental Journal. 23(2): 114-123.

Abstracts

Oral presentation

Cruz E, Liu SS, Blanchard SB, Stewart K, Soto A, Allen MR. Effects of the diameter of orthodontic mini-implants on microdamage in the dog maxilla and mandible. American Association of Orthodontists 112th annual session, Honolulu, Hawaii, 2012

Zapata U, Liu S, Jun S, Elsey RM, Wang Q. Changes in micro-architectural characteristics of mandibular sutures using micro-CT images in American Alligators during ontogeny. FASEB J March 29, 2012 26:457.2

Liu SS, Sun J, Fanning M, Martinez-Mier EA, Li S, Kula K, Stewart KT. Can fluoride prevent genetically predisposed root resorption in tooth movement? J Dent Res 91 (Spec Iss A): 157514, 2012

Li S, Chen J, Liu SS, Kula K, Viecilli R. A comparison of movement rate in two canine retraction strategies, J Dent Res 91 (Spec Iss A): 157283, 2012

Xia Z, Chen J, Liu SS, Jiang F, Viecilli R. Change of loadings delivered by segmental T-loops for canine retraction. J Dent Res 91 (Spec Iss A): 156068, 2012

Cruz E, Liu SS, Blanchard SB, Stewart K, Soto A, Allen MR. Effects of the diameter of orthodontic mini-implants on microdamage in the dog maxilla and mandible. World Implant Orthodontic Conference, 10/07 2011

Yadav S, Upadhyay M, Liu SS, Chen J. Katona T, Nanada R, and Roberts WE. Relationship between surface properties and removal torque of orthodontic miniscrews. J Dent Res 90 (Spec Iss A): 127, 2011

Liu SS, LA Opperman, Buschang PH. The effects of rhBMP-2 on midsagittal sutural expansion, J Dent Res 88 (Sec Iss A): 272 2009

Carrell T, Liu SS, Opperman LA, Buschang. Does bone around 3mm miniscrew implants adapt to varying forces? J Dent Res 88 (Sec Iss A): 272 2009

Liu SS and Buschang PH. Is the lower dental molar eruption adapting to mandibular displacement? J Dent Res 87 (Spec Iss A): 804, 2008

Poster presentation

Romanyk DL, Lagravere MO, Toogood RW, Liu SS, Lipsett MG, Major PW, Carey JP. American Association of Orthodontists 112th annual session, Honolulu, Hawaii, 2012

Labban N, Aref M, Brown D, Allen M, Bruzzaniti A, Liu S, Winsor LJ. BENS, Bone and Connective Tissue Regeneration Agent for Osteoporosis. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P5, April 2012

Yoshida T, Sun J, Liu S, Platt JA. Construction of 3D Tooth Models for Endodontic Research and Education: Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 27, April 2012

Ahn EJ, Kula K, Liu S, Stewart KT, Eckert G, Halum S, Dillehay JK, Eraso F, Ghoneima A. Three-Dimensional Airway Volumes and Most Constricted Areas in Children. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 47, April 2012

Hansen V, Schrader S, Liu S, Vargus B, Dean J, Stewart KT. Personality as a Predictor of Willingness to Undergo Orthodontic Treatments. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 52, April 2012

Hungate K, Kang H, Liu S, Kula K, Stewart KT. Inclusion of Second Molars and Outcomes of Orthodontic Treatment. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 54, April 2012

Taing-Watson E, Stewart KT, Liu S. Systematic Review of Transposed Teeth. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 56, April 2012

Cruz Marroquin E, Liu S, Sun J, Blanchard SB, Soto-Rojas AE, Stewart KT, Allen MR. Effects of Orthodontic Mini-implant Diameter on Microdamage. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 59, April 2012

Wu D, Chen J, Isikaby S, Xia Z, Stewart KT, Liu S. How to Prevent Tooth Rotation During Orthodontic Space Closure. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 60, April 2012

Liu S, Sun J, Fanning, M, Martinez-Mier EA, Li S, Kula K, Stewart KT. Can Fluoride Prevent Genetically Predisposed Root Resorption in Tooth Movement?  Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 61, April 2012

Xia Z, Chen J, Liu S, Jiang F, Viecilli. Change of Loadings Delivered by Segmental T-Loops for Canine Retraction. Indiana University School of Dentistry Research Day, 20th Annual proceedings: P 61, April 2012

Kula KS, Ahn EJ, Liu SS, Stewart K, Eckert G, Halum S, Dillehay JK, Eraso F, Ghoneima A. Three-dimensional airway volumes and most constricted areas in children. J Dent Res 91 (Spec Iss A): 157829, 2012

Hungate K, Kang HK, Liu SS, Kula K, Stewart KT. Inclusion of second molars and outcomes of orthodontic treatment. AADR/CADR 41st Annual Meeting and Exhibition, J Dent Res 91 (Spec Iss A): 156430, 2012

Elsahy SS, Liu S, Sun J, Dunn-Jena P, Stewart KT. Effects of fluoride on condylar growth and density. J Dent Res 91 (Spec Iss A): 156889, 2012

Stewart KT, Larrabee T, Torres-Gorena AA, Soto-Rojas AE, Liu SS. Effects of alcohol on force decay of elastomeric chain. J Dent Res 91 (Spec Iss A): 157663, 2012

Dodge T, Theriac H, Sempsrott K, Carter C, Largura H, Bruzzaniti A, Liu S. Effects of mini implant screws on osteoclast and osteoblast differentiation. IUPUI Research Day: 11, April 2011

Theriac H, Dodge T, Largura H, Hara A, Liu S, Bruzzaniti A. Effects of mini implant screws on osteoclast and osteoblast differentiation. IUPUI Research Day: 50, April 2011

Elsahy SS, Liu S, Sun J, Dunn-Jena P, Stewart KT. Effects of fluoride on condylar growth and density. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P16, April 2011

Dodge T, Therica H, Carter C, Sempsrott K, Largura H, Liu S. Bruzzaniti A, Effect of mini Implant screws on osteoclast and osteoblast differentiation Indiana University School of Dentistry Research Day, 19th Annual proceedings: P19, April 2011

Therica H, Dodge T, Carter C, Largura H, Hara A, Liu S. Bruzzaniti A, Role of osteoclasts in Biocorrosion of metal implants. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P20, April 2011

Li S, Chen J, Kula K, Ellis P, Liu S. Quantification of Clinical 3D Tooth Displacement. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P54, April 2011

Ponder J, Wiseman K, Allen M, Sun J, Stewart KT, Cruz E, Dunn-Jena P, Liu S.  Assessment of microdamage caused by mini-implants in mandible and maxilla. Hinman Student Research Symposium, Oct 2011

Ponder J, Wiseman K, Allen M, Sun J, Stewart KT, Cruz E, Dunn-Jena P, Liu S.  Assessment of microdamage caused by mini-implants in mandible and maxilla. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P55, April 2011

Smith T, Ghoneima A, Stewart KT, Baldwin J, Liu S, Eckert GJ, Halum S, Kula KS. Three-dimensional CT analysis of airway volume following RME treatment. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P56, April 2011

Stewart KT, Larrabee T, Torres-Gorena A, Soto-Rojas AE, Platt J, Liu S. Effects of alcohol on the force degradation of elastomeric chains Indiana University School of Dentistry Research Day, 19th Annual proceedings: P57, April 2011

Al Hosainy A, Li S, Chen J, Dean J, Liu S. A novel 3D technology to evaluate root canal instrumentation. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P61, April 2011

Al Hosainy A, Liu S, Dean J, Elkala I. Ex-vivo evaluation of electronic apex locator accuracy in primary molars. Indiana University School of Dentistry Research Day, 19th Annual proceedings: P63, April 2011

Li S, Liu SS, Chen J. A 3D approach to mandibular superimposition and measure condylar changes. J Dent Res 90 (Spec Iss A):1571, 2011

Li S, Chen J, Liu SS. Quantification of clinical 3D tooth displacement. J Dent Res 90 (Spec Iss A):1513, 2011

Zapata U, Liu S, Sun J, Elsey RM, Wang Q. Ontogenetic changes in the microarchitecture of sutures in the American alligator (Alligator Missipienssis). FASEB J March 17, 2011 25:489.

Carter C, Sempsrott K, Liu S, Bruzzaniti A. Osteoblast differentiation and mineralization on stainless steel and titanium-alloy mini implant screw. Center for Research and Learning, summer research programs poster symposium: P115, July 2010

Theriac H, Dodge T, Liu S, Bruzzaniti A. Osteoclast differentiation on stainless steel and titanium-alloy mini-implant screw, Center for Research and Learning, summer research programs poster symposium: P116, July 2010

Yadav S, Liu SS, Chen J, Katona T, Huja SS, Roberts WE. Histomorphometric and biomechanical analyses of osseointegration of four different implant surfaces. Indiana University School of Dentistry Research Day, 18th Annual proceedings: P56, April 2010

Whittington P, Misner K, Xu H, Buschang PH, Opperman LA, Liu S. rhBMP-2 affects sagittal sutural expansion and percent fusion, J Dent Res 88(Spec Iss A):973, 2010

Misner K, Whittington P, Xu H, Liu S, Buschang PH, Opperman LA. rhBMP-2 treatment decreases sagittal sutural width after expansion, J Dent Res 88(Spec Iss A):968, 2010

Opperman LA, Xu H, , Dechow PC, Buschang PH, Liu S, Recombinant human bone morphogenetic protein-2 affects midsagittal sutural expansion. Proceedings of the thirteen congress of the International Society of Craniofacial Surgery and Paris Distraction Symposium: 233, September 2009

Brugler B, Liu SS, Kyung HM, Ceen RF, Buschang PH. A novel mini-screw implant approach to sutural expansion, J Dent Res 86 (Spec Iss A): 760, 2007

Liu SS, Brugler B, Kyung HM, Ceen RF, Buschang PH, Opperman LA. Suture adaptation to constant and intermittent expansion forces, J Dent Res 86 (Spec Iss A): 768, 2007

Liu S, So S, Hinton R. In vitro movement and chondrogenesis/ osteogenesis in mandibular condylar cartilage. J Dent Res 85 (Spec Iss A): 1234, 2006

Liu S, Tsai CY, Su B, Chang CY, Cheng HC. Bone regulation and serum IGFBP-5 changes in orthodontic treatment. J Taiwan Assoc Orthod 14 (Suppl), 2003

Cheng HC, Liu S, Chan, Y, Kao G, Lin L, Tsai, CY. Orthodontic treatment and dental laser bleaching. J Taiwan Assoc Orthod 13 (Suppl), 2002

Cheng HC, Liu S, Chi L, Peng B. Dental laser bleaching after orthognathic surgery. J Taiwan Assoc Orthod 13 (Suppl), 2002