Angela Bruzzaniti, PhD

Angela Bruzzaniti, PhD
Angela Bruzzaniti, PhD

Associate Professor
Department of Biomedical and Applied Sciences
School of Dentistry

Adjunct Associate Professor
Department of Anatomy and Cell Biology
School of Medicine

Contact Info

Phone  (317) 278-3742
Fax       (317) 278-1411

Office Address

Indiana University School of Dentistry
1121 W. Michigan Street, DS 243
Indianapolis, Indiana 46202


For a complete publication list, please visit the following sites;


Peer-Reviewed Publications 

Bethel M, Barnes CL, Taylor AF, Cheng YH, Chitteti BR, Horowitz MC, Bruzzaniti A, Srour EF, Kacena MA. A novel role for thrombopoietin in regulating osteoclast development in humans and mice. J Cell Physiol. 2015 230:2142-51. PMID: 25656774; PMCID: PMC4447549.

Rowe MJ, Kamocki K, Pankajakshan D, Li D, Bruzzaniti A, Thomas V, Blanchard SB, Bottino MC. Dimensionally stable and bioactive membrane for guided bone regeneration: An in vitro study. J Biomed Mater Res B Appl Biomater. 2015 May 7. doi: 10.1002/jbm.b.33430. [Epub ahead of print] PubMed PMID: 25953329

Pacheco-Costa R, Hassan I, Reginato RD, Davis HM, Bruzzaniti A, Allen MR, Plotkin LI. High bone mass in mice lacking Cx37 because of defective osteoclast differentiation. J Biol Chem. 2014 Mar 21;289(12):8508-20. doi:10.1074/jbc.M113.529735. Epub 2014 Feb 7. PMID: 24509854; PMCID: PMC3961675.

Eleniste PP, Huang S, Wayakanon K, Largura HW, Bruzzaniti A. Osteoblast differentiation and migration are regulated by dynamin GTPase activity. Int J Biochem Cell Biol. (2014) 46:9-18. PubMed PMID: 24387844

Huang S, Eleniste PP, Wayakanon K, Mandela P, Eipper BA, Mains RE, Allen MR, Bruzzaniti A. The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts. Bone. 2013 Dec 28. pii: S8756-3282(13)00545-0. doi: 10.1016/j.bone.2013.12.023. [Epub ahead of print] PubMed PMID: 24380811

Cheng YH, Hooker RA, Nguyen K, Gerard-O’Riley R, Waning DL, Chitteti BR, Meijome TE, Chua HL, Plett AP, Orschell CM, Srour EF, Mayo LD, Pavalko FM, Bruzzaniti A, Kacena MA. Pyk2 Regulates Megakaryocyte-Induced Increases in Osteoblast Number and Bone Formation, J Bone Miner Res. (2013) 28(6):1434-45. PMID 23362087

Eleniste P, Bruzzaniti A. Focal adhesion kinases in adhesion structures and disease. Journal of Signal Transduction, vol. 2012, Article ID 296450, 12 pages (2012) oi:10.1155/2012/296450 PMID: 22888421 PMCID: PMC3409539

Kacena MA, Eleniste P, Cheng Y-H, Huang S, Shivanna M, Meijome T, Mayo LD, Bruzzaniti A. Megakaryocytes Regulate the Expression of Pyk2 isoforms and the Caspase-Mediated Cleavage of Actin in Osteoblasts. Journal of Biological Chemistry, 287(21):17257-68 (2012) PMID: 22447931 PMCID: PMC3366857

Eleniste P, Du L, Shivanna M, Bruzzaniti A. Dynamin and PTP-PEST Cooperatively Regulate the Dephosphorylation of Pyk2 in Osteoclasts. International Journal of Biochemistry and Cell Biology. 44(5):790-800 (2012). PMID:22342188 PMCID: PMC3319480

Nickerson NK, Mohammad KS, Jennifer L. Gilmore JL, Crismore E, Bruzzaniti A, Guise TA, Foley J. Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad. PLoS Biology, 2012;7(1):e30255. PMID: 22276166 PMCID: PMC3261896

Childress P, Philp BK, Robling AG, Bruzzaniti A, Kacena MA, Bivi N, Plotkin LI, Heller A, Bidwell JP. Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts. Calcified Tissue International. 2011; 89:74-89. PMID: 21607813 PMCID: PMC3200195

Bruzzaniti A, Neff L, Sandoval A, Du L, Horne WC, Baron R. Dynamin reduces Pyk2 Y402 phosphorylation and Src binding in Osteoclasts. Molecular and Cellular Biology, 29:3644-56 (2009). PMID: 19380485 PMCID: PMC2698752

Gil-Henn H, Destaing O, Sims NA, Aoki K, lles NA, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J. Defective Pyk2-mediated Podosome Organization in Osteoclasts Leads to Osteopetrosis in Pyk2-/- mice. Journal of Cell Biology, 178:1053-64 (2007). PMID: 17846174 PMCID: PMC2064627

Bruzzaniti A, Neff L, Sanjay A, Horne WC, De Camilli P, Baron R. Dynamin Forms a Src-Kinase-sensitive Complex with Cbl and Regulates Podosomes and Osteoclast Activity. Molecular Biology of the Cell, 16:3301-3313 (2005). PMID: 15872089 PMCID: PMC1165412

Bruzzaniti A, Mains RE. Enzymatic Activity of Soluble and Membrane Tethered Peptide Prohormone Convertase 1, Peptides, 23:863-875 (2002). PMID: 12084516

El Meskini R, Jin L, Marx R, Bruzzaniti A, Lee J, Emeson R, Mains RE. A Signal Sequence is Sufficient for Green Fluorescent Protein to be Routed to Regulated Secretory Granules. Endocrinology, 142:864-73 (2001). PMID: 11159860

Bruzzaniti A, Marx R, Mains RE. Activation and Processing of Membrane-tethered Prohormone Convertase 1 and 2. Journal of Biological Chemistry, 274:24703-24713 (1999). PMID: 10455138

Bruzzaniti A, Goodge K, Jay P, Taviaux SA, Lam MHC, Berta P, Martin TJ, Moseley JM, Gillespie MT. PC8, A New Member of the Convertase Family. Biochemical Journal, 314:727-731 (1996). Erratum in Biochem J 1996 316:1007. PMID: 8615762 PMC1217117


Book Chapters and Review Articles 

Allam E. Eleniste PP, Bruzzaniti A, Windsor J. Osteoblast Functions and their Role in Skeletal Bone Diseases. In "Osteoblasts: Morphology, Functions and Clinical Implications" Ed Brown J., Walker JS, Nova Science Publishers, Inc. NY, pages 63-82 (2013)

Bethel M, Bruzzaniti A, Kacena MA. Osteoclast Formation and Function and its Role in Skeletal Bone Disease. In Osteoclasts: Morphology, Functions, and Clinical Implications. Ed Brown J, Walker JS, Nova Science Publishers, Inc. Hauppauge, NY, 2:1-22 (2012)

Bruzzaniti A and Baron R. Molecular Regulation of Osteoclast Activity. Reviews in Endocrine and Metabolic Disorder, 7:123-39 (2006). PMID: 16951988

Bruzzaniti A. The Biology of Osteoporosis: Examination of Key Proteins Involved in Bone Loss. Innovations in Women’s Health, Yale University, 4:7 (2005)

Horne WC, Sanjay A, Bruzzaniti A, Baron R. The Role(s) of Src Family Kinases and Cbl Proteins in the Regulation of Osteoclasts. Immunological Reviews, 208:106-125 (2005). PMID: 16313344

Research Interests

The maintenance of bone mass in adult life depends upon the coordinated activities of both the osteoblasts, which make new bone, and the osteoclasts, the cells responsible for bone degradation. In skeletal diseases such as osteoporosis, Paget’s disease and hypercalcemia of malignancy, unregulated bone resorption by osteoclasts results in low bone mass, skeletal fragility and increased risk of bone fracture. The metabolic bone diseases and periodontitis also result in alveolar bone loss, tooth mobility and ultimately, tooth loss. 

Osteoclast adhesion and migration along the bone surface involves remodeling of its cytoskeleton and the assembly, organization and disassembly of specialized adhesion structures named podosomes. My laboratory is focused on identifying and characterizing key intracellular signaling proteins and protein complexes that are involved in regulating the attachment, migration and bone resorbing activity of osteoclasts. To this end, we are currently using a number of transgenic and knockout mice to investigate the role of specific tyrosine kinases, actin-regulatory proteins and GTP-binding/hydrolyzing proteins in regulating osteoclast function. 



Ph.D. in Biochemistry and Molecular Biology, The University of Melbourne and St. Vincent’s Institute of Medical Research, Victoria, Australia. 

Postdoctoral Fellowship, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Associate Research Scientist, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA. 

Click here to visit Dept. of Biomedical and Applied Sciences research interests.