Early Caries Detection and Management


 

Main Goal

To develop/evaluate new technologies for the early detection of dental caries.

Specific Goals

The primary objectives of the Early Caries Detection and Management Program are to:

  • Evaluate and validate new technologies being developed for the early detection of dental caries (primary, secondary and root surface caries)

  • Utilize these new technologies to identify more efficient measures for the prevention and control of dental caries

Program Director
Dr. Masatoshi Ando

Other Faculty Supporting the Program
Dr. Judith R. Chin
Dr. Richard D. Jackson
Dr. George Stookey
Dr. Domenick T. Zero

 

Publications

Published in Refereed Journals

  1. Ferreira Zandona, A., Ando, M., Gomez, G.F., Garcia-Corretjer, M., Eckert, G.J., Santiago, E., Katz, B.P., Zero, D.T.: Longitudinal Analyses of Early Lesions by Fluorescence ‚Äď an Observational Study. Journal of Dental Research 2013;92(Suppl 1):84S-89S.
     
  2. Ferreira Zandona AG,¬†Santiago E, Eckert GJ, Katz BP, Pereira de Oliveria S, Capin OR, Mau M, Zero DT. The Natural History of Dental Caries Lesions ‚Äď a 4 Year Observational Study. J D Res 2012;91(9):841 - 846.DOI 10.1177/0022034512455030
     
  3. Yassen G. Lippert F, Eckert GJ, Ferreira Zandona AG. Dose-response effects of strontium and fluoride on caries lesion remineralization. Quintessence Int  2012 Jun;43(7):e95-e103.
     
  4. Fontana,M., Jackson, R., Eckert, G., Swigonski, N., Chin,J., Ferreira Zandona,A., Ando,M., G.K. Stookey,G.K., Downs,S., Zero, D.: Identification of caries risk factors in toddlers. Journal of Dental Research 2011;90:209-214.
     
  5. Fontana M, Santiago E, Eckert GJ, Ferreira Zandona AG. Longitudinal Assessment of Caries Risk Factors in a Hispanic School-Age Population. J Dent Res 2011, Oct;90(10):1189-96 PMID 21765039
     
  6. Ferreira Zandona AG. Evolution of Caries Diagnosis. Dimensions of Dent Hygiene 2011; 9(9):84-87
     
  7. Diniz MB, Liam LM, Eckert G, Ferreira Zandona AG, Cordeiro RCL, Santos-Pinto L. In vitro evaluation of ICDAS and radiographic examination of occlusal surfaces and their association with treatment decisions. J Oper Dent 2011, 36-2, 133-142.
     
  8. Zero DT, Ferreira Zandona AG, Macapagal Vail M, Spolnik KJ. Dental caries and pulpal disease. In: Contemporal Conecepts in the Diagnosis of Oral and Dental Disease. Dent Clinics of North Amer 2011; 55(1):29-46.
     
  9. Pereira-Oliveira S; Ferreira-Zandona A; Ando M, Zero DT, Froes de Freitas C. Optimizing Microcomputed tomography settings for caries detection. Dentomaxillofac Radiol (submitted)
     
  10. Ando, M., Eckert, G.J., Zero D.T: Preliminary Study to Establish a Relationship of Tactile Sensation with Surface Roughness. Caries Res 2010;44:24-28 (DOI: 10.1159/000275570).
     
  11. Zandona, A.G.F.; Santiago, A.; Eckert, G.J.; Fontana,M., Ando, M.; Zero, D.T.: The Use of ICDAS Combined with QLF as a Caries Detection Method. Caries Res 2010;44:3:317-322.
     
  12. Ferreira Zandona AG, Al-shiha S, Eggertsson H. Student versus faculty performance using a new visual criteria for the detection of caries on occlusal surfaces: An In Vitro Examination with Histological Validation. J Oper Dent 2009;September-October 34(5):598-604.
     
  13. Fontana M, Catt D, Sissons S, Eckert G, Ofner S Toro M, Gregrory RL, , Ferreira Zandona A, Eggertsson H, Jackson R, Chin J, Zero D. Xylitol: Effects on the Acquisition of Cariogenic Species in Infants. Pediatric Dentistry 2009; May-June 31(3):257-266.
     
  14. Zero, D.T., Fontana,M., Martinez-Mier, E.A., Zandona, A.G.F., Ando, M, Gonz√°lez-Cabezas, C., Stephen, B.: The Biology, Prevention, Diagnosis and Treatment of Dental Caries. Scientific Advances in the United States. Journal of American Dental Association 2009; 140, Suppl 1, 25S-34S.
     
  15. Tagtekin, D. A., Ozyoney, G., Baseren, M., Ando, M., Hayran, O., Alpar, R., Gokalp, S., Yanikoglu, F. C., Stookey, G.K.: Detection of Enamel Caries by DIAGNOdent and Ultrasonics. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2008;106:729-735.
     
  16. Diniz MB, Liam LM, Santos-Pinto L. Eckert G, Ferreira Zandona AG, Cordeiro RCL, Influence of the ICDAS E-Learning Program for Occlusal Caries Detection on Dental Students. J Dent Educ. 74(8): 862-868
     
  17. Stahl J, Ferreira Zandona AG. Rationale and protocol for the treatment of non-cavitated smooth surface carious lesions. General Dent 2007 Mar-Apr;55(2):105-11
     
  18. Ando, M., Stookey, G.K., Zero D.T: Ability of Quantitative Light-induced Fluorescence (QLF) to Assess the Activity of White-Spot Lesions During Dehydration. American Journal of Dentistry 2006;19:15-18.
     
  19. Ferreira Zandona AG, Zero DT. Diagnostic tools for ealy caries detection. J Am Dent Assoc 2006; 137: 1675-1684
     
  20. Hara, A.T., Ando, M., Gonz√°lez-Cabezas, C., Cury, J.A., Serra, M.C., Zero, D.T: Protective Effect of the Acquired Dental Pellicle Against Different Erosive Challenges in situ. Journal of Dental Research 2006;85 (7):612-616.
     
  21. Hara, A.T., Turssi, C.P., Ando, M., Gonz√°lez-Cabezas, C., Zero, D.T., Rodrigues Jr., A.L., Serra, M.C., Cury, J.A.: Influence of Fluoride-Releasing Restorative Material on Root Dentine Secondary Caries in situ. Caries Research 2006;40:435-439.
     
  22. Hara, A.T., Ando, M., Cury, J.A., Serra, M.C., Gonz√°lez-Cabezas, C., Zero, D.T: Influence of the Organic Matrix on Root Dentine Demineralisation by Erosive Acid. Caries Research 2005;39:134-138.
     
  23. Ando, M., Eckert, G.J., Stookey, G.K., Zero D.T: Effect of Imaging Geometry on Evaluating Natural White-spot Lesions Using Quantitative Light-induced Fluorescence. Caries Research 2004; 38: 39-44.
     
  24. Ando, M., Gonz√°lez-Cabezas, C.; Isaacs,L.R.; Eckert, G.J., Stookey, G.K.: Evaluation of Several Techniques for the Detection of Secondary Caries Adjacent to Amalgam Restorations. Caries Research 2004; 38:350-356. (DOI: 10.1159/000078181)
     
  25. Stookey GK, Mau MS, Isaacs RL, Gonzalez-Gierbolini C, Bartizek RD, Biesbrock AR. The relative anticaries effectiveness of three fluoride-containing dentifrices in Puerto Rico. Caries Res 2004;38:542-550.
     
  26. Stookey GK: Optical methods---Quantitative light fluorescence. J Dent Res 2004;83(Spec Iss C):C84-C88.
     
  27. Ando, M., Schemehorn, B.R., Zero D.T., Stookey, G.K.: Influence of Enamel Thickness on Quantification of Mineral Loss in Enamel Using Laser-induced Fluorescence. Caries Research 2003; 37: 24-28.
     
  28. Gonz√°lez-Cabezas C, Fontana M, Gomes Moosbauer D, Stookey GK: Early Detection of secondary caries using quantitative light-induced fluorescence. Oper Dent 2003;28:415-422.
     
  29. Stookey GK: The evolution of caries detection. Dimensions of Dental Hygiene 2003;1: 12-15.
     
  30. van der Veen, M.H.; Ando, M., de Josselin de Jong, E; Stookey, G.K.: A Monte-Carlo Simulation of the Influence of Sound Enamel Scattering Coefficient on Lesion Visibility in Light-induced Fluorescence. Caries Research 2002; 36: 10-18.
     
  31. Buchalla W, Lennon AM, van der Veen MH, Stookey GK: Optimal camera and illumination angulations for detection of interproximal caries using quantitative light-induced fluorescence. Caries Res 2002;36:320-326.
     
  32. Lennon √ĀM, Buchalla W, Switalski L, Stookey GK: Residual caries detection using visible fluorescence. Caries Res 2002;36:315-319.
     
  33. Fontana M, Gonzalez-Cabezas C, Haider A, Stookey GK: Inhibition of secondary caries lesion progression using fluoride varnish. Caries Res 2002;36:129-135.
     
  34. Ando, M., van der Veen, M.H.; Schemehorn, B.R., Stookey, G.K.: Comparative Study to Quantify Demineralized Enamel in Deciduous and Permanent Dentition using Laser- and Light-induced Fluorescence Techniques. Caries Research 2001; 35: 464-470.
     
  35. Stookey GK, Gonzalez-Cabezas C: Emerging methods of caries diagnosis. J Dent Educ 2001;65:1001-1006.
     
  36. Yanikoglu FC, Ozturk F, Hayran O, Analoui M, Stookey GK: Detection of natural white spot caries lesions by an ultrasonic system. Caries Res 2000;34:225-232.
     
  37. Lagerweij, M.D.; ven der Veen, M.H.; Ando, M.; Lukantsova, L.; Stookey, G.K.: The Validity and Repeatability of Three Light-induced Fluorescence Systems: An in vitro Study. Caries Research 1999; 33: 220-226.
     
  38. Ando, M., Hall, A.F., Eckert, G.J., Schemehorn, B.R., Analoui, M., Stookey, G.K.: Relative ability of laser fluorescence techniques to quantitate early mineral loss in vitro. Caries Research 1997; 31:125-131.
     
  39. Hall, A.F., DeSchepper E., M. Ando., Stookey G.K.: In Vitro Studies of Laser Fluorescence for Detection and Quantification of Mineral Loss from Dental Caries. Advances in Dental Research 1997; 11(4): 507-514.
     
  40. Ando, M: Effect of Fluorosurfactant on the Adsorption of Protein to Synthetic Hydroxyapatite. Shika Igaku (J Osaka Odontol Soc) 56 (1): 1-16, 1993.

 

 

Published in Refereed Journals / Conference Proceedings

  1. Zhang, H.; Ruan, G.; Boyles, M.; Ando, M.: XSEDE-Enabled High-Throughput Lesion Activity Assessment. eXtreme Science and Engineering Discovery Environment (XSEDE) 2013, 10:1-10:8, (DOI: 10.1145/2484762.2484783).
     
  2. Zhang, H.; Ando, M., Boyles, M.: 3D-Time Series Analysis of Caries Lesion Activity for Oral Health Care; in Proceedings of the IEEE VisWeek Workshop on Visual Analytics in Healthcare: Open Health Data 2012. Seattle WA., pp 32-35.
     
  3. Zhang, H.; Li, H.; Boyles, M.J.; Henschel, R.; Kohara, E.K.; Ando, M.: Exploiting HPC Resources for the 3D-Time Series Analysis of Caries Lesion Activity. eXtreme Science and Engineering Discovery Environment (XSEDE) 2012, 19:1-19:8, (DOI: 10.1145/2335755.2335815).

 

 

Invited Paper

  1. Ando, M: Digital Imaging Fiber Optics Trans-Illumination for Detection of Non-cavitated Lesions; in Stookey G.K., Kambara M (eds): 83rd General Session International Association for Dental Research Baltimore, Maryland: Symposium Early Detection of Dental Caries. Indianapolis, In., Moeller Printing Co., Inc., 2006, pp 41-52.
     
  2. Ando, M: Early Detection of Dental Caries with Quantitative Light-induced Fluorescence (QLF). Nippon Dental Review 63 (6): 155-160, 2003.

 

 

Published in Edited Books

  1. Ando, M; Sharp, N; Adams, D: Pulse thermography for quantitative nondestructive evaluation of sound, de-mineralized and re-mineralized enamel; in Kundu, Tribikram (ed): Proceedings in Health Monitoring of Structural and Biological Systems 2012, SPIE (vol 8348).¬† San Diego CA., Society of Photo-Optical Instrumentation Engineers (SPIE) ‚ÄďThe International Society for Optical Engineering, 2012, DOI: 10.1117/12.914371.
     
  2. Wefel J.S; Ando, M; Harless J.D: Other Instrumental Detection Methods for Caries Clinical Trials; in Stookey, George K (ed): Clinical Models workshop: Remin-Demin, Prevention, Caries. Indianapolis, In., Indiana University, School of Dentistry, 2005, pp 237-250.
     
  3. Ando, M; Aurora, P; Doi, T; Schemehorn, R.B; Eckert, J.G, Stookey G.K: Characteristics of Early Stage of Enamel Demineralization in vitro; in Stookey, George K (ed): Early Detection of Dental Caries III. Indianapolis, In., Indiana University, School of Dentistry, 2003, pp 363-373.
     
  4. Eggertsson, H.; Ferreira Zandon√°, A.G; Ando, M; Gonz√°lez-Cabezas, C.; Fontana, M; Martinez-Mier A.E.; Waskow-Chin J.R.; Jackson R.D.; Eckert, J.G, Stookey G.K.; Zero D.T.: Reproducibility of in vitro and clinical examinations with QLF (Quantitative Light-induced Fluorescence). Developing guidelines for imaging and analyzing QLF images, and a process for training examiners; in Stookey, George K (ed): Early Detection of Dental Caries III. Indianapolis, In., Indiana University, School of Dentistry, 2003, pp 213-228.
     
  5. Ferreira Zandon√° AG, Stookey GK, Eggertsson H, Wefel J, Katz B, Ofner S, Eckert G: Clinical validation study of QLF at Indiana. In: Stookey GK, ed. Early detection of dental caries III: proceedings of the 6th annual Indiana Conference. Indianapolis, Indiana: Indiana University School of Dentistry 2003:237-252.
     
  6. Gonz√°lez-Cabezas C, Fontana M: Current research using new technologies for the detection and monitoring of secondary caries. In: Stookey GK, ed. Early detection of dental caries III: proceedings of the 6th annual Indiana Conference. Indianapolis, Indiana: Indiana University School of Dentistry 2003:347-362.
     
  7. Ando, M; Eggertsson, H.; Isaacs,R.; Analoui, M; Stookey G.K: Comparative Studies of Several Methods for the Early Detection of Fissure Lesions; in Stookey, George K (ed): Early Detection of Dental Caries II. Indianapolis, In., Indiana University, School of Dentistry, 2000, pp279-299.
     
  8. Fontana, M; √áalńĪŇükan YanńĪkońülu, F.; √Ėzt√ľrk, F.; Ando, M; Hayran, O.; Gonz√°lez-Cabezas, C.; Haider A.; Baldridge L.; Stookey G.K: Comparison of QLF, Ultrasound and Confocal Microscopy in the Measurement of Demineralization / Remineralization of Enamel Lesions Developed on Natural Smooth Surfaces; in Stookey, George K (ed): Early Detection of Dental Caries II. Indianapolis, In., Indiana University, School of Dentistry, 2000, pp301-316.
     
  9. Analoui, M, Eggertsson H, Stookey GK: Quantitative radiographic techniques for caries detection and analysis. In: Stookey GK, ed. Early detection of dental caries II: proceedings of the 4th annual Indiana Conference. Indianapolis, Indiana: Indiana University School of Dentistry 2000;185-202.
     
  10. Ferreira Zandon√° A, Isaacs RL, van der Veen M, Stookey GK: Indiana pilot clinical study of quantitative Light Fluorescente. In: Stookey GK, ed. Early detection of dental caries II: proceedings of the 4th annual Indiana Conference. Indianapolis, Indiana: Indiana University School of Dentistry 2000:219-230.
     
  11. Gonz√°lez-Cabezas, C.; Fontana, M; Gomes-Moosbauer D.; Ando, M; Analoui M.; Stookey G.K: Comparative Studies of Several Methods for the Early Detection of Secondary Caries; in Stookey, George K (ed): Early Detection of Dental Caries II. Indianapolis, In., Indiana University, School of Dentistry, 2000, pp317-342.
     
  12. Analoui, M; Ando, M; Stookey, G.K: Comparison of Reflectance Spectra of Sound and Carious Enamel; in Featherstone JDB, Rechmann P, Fried D and Katzir A (eds): Proceedings in Laser in Dentistry V (vol 3910).¬† Bellingham, Wash., Society of Photo-Optical Instrumentation Engineers (SPIE) ‚ÄďThe International Society for Optical Engineering, 2000, pp 227-234.
     
  13. Ando, M; Analoui, M; Schemehorn, B.R; Stookey, G.K: Comparison of light-induced and laser-induced fluorescence methods for the detection and quantification of enamel demineralization; in Feahterstone JDB, Rechmann P, Fried D and Katzir A (eds): Proceedings in Laser in Dentistry V (vol 3593).¬† Bellingham, Wash., Society of Photo-Optical Instrumentation Engineers (SPIE) ‚ÄďThe International Sociaty for Optical Engineering, 1999, pp 148-153.
     
  14. Stookey, G.K; Isaaca, R.L; Ferreira Zandon√°, A.G; Ando, M; Gonzalez, C; Mau, M.S; Kelly, S.A; Analoui, M: Clinical validation of the use of fluorescence for the early detection of dental caries; in Feahterstone JDB, Rechmann P, Fried D and Katzir A (eds): Proceedings in Laser in Dentistry V (vol 3593). Bellingham, Wash., Society of Photo-Optical Instrumentation Engineers (SPIE) ‚ÄďThe International Society for Optical Engineering, 1999, pp 154-157.
     
  15. Hall, A.F.; Ando,M; Schemehorn, B.R.; Stookey, G.K: Dye-enhanced laser fluorescence method; in Stookey, George K (ed): Early Detection of Dental Caries I. Indianapolis, In., Indiana University, School of Dentistry, 1996, pp 119-144.