The Explorer

DS114 - IUSD

Tuesday, December 16th 2014
12:00-1:00 PM

“Beyond Probing and Radiographs: Novel Optical Diagnostic Modalities in the Oral Cavity” 

Presented By 

Dr. Petra Wilder-Smith,

BDS (Hons.), L.D.S.  R.C.S. (Eng.),

Dr. med. Dent., Ph.D. (Habil.)

Professor and Director of Dentistry at the University of California,

Irvine’s Beckman Laser Institute (BLI)

Use of light for optical diagnostics provides the opportunity for non-invasive, instant, targeted detection, diagnosis and monitoring of oral pathologies. In this lecture, we very briefly present an overview of the different mechanisms that can be used for optical imaging in the oral cavity, providing an understanding of their individual strengths and limitations. Modalities that will be discussed include spectroscopy, endogenous and photosensitizer-induced fluorescence mapping, Optical Coherence and Optical Doppler Tomography techniques, Laser Speckle techniques and various forms of Non-Linear Optical Microscopy. Then their clinical usefulness for specific conditions including oral dysplasia and malignancy, periodontal disease, demineralization and decay, as well as cancer-therapy-induced mucositis will be evaluated based on a wide range of imaging studies. Whilst our initial research was often performed ex vivo, we have progressed to the use of in vivo non-invasive technologies in animals and humans for our multi-modality approach.

An overview of clinical needs and of the specific strengths and weaknesses of each imaging approach will be presented. Data from our pre-clinical and clinical imaging studies in the oral cavity will be shown and potential future developments will be presented.