Chandler L. Walker, BS, MS, PhD

Chandler L. Walker, BS, MS, PhD
Chandler L. Walker, BS, MS, PhD

Assistant Professor, Biomedical and Applied Sciences


Contact Info

(317) 278-1402 (Phone)

(317) 278-1411 (Fax)

Office Address

Indiana University School of Dentistry
Department of Biomedical and Applied Sciences
1121 W. Michigan Street, Room 112D
Indianapolis, Indiana  46202


Narrative of Professional Career

My research focuses on understanding the progression of tissue pathology following peripheral and central nervous system injuries and diseases, and how pharmacological, cell-based, and combination therapies can improve anatomical and neurological outcome. Cellular and molecular mechanisms of how these therapies act are also of great interest.

Professional Interests

Editorial Board
• Journal of Neurorestoratology (2015-Present)
• Consulting Editor: Journal of Neurorestoratology (2015-Present)

Journal Peer Review
• Scientific Reports
• British Journal of Pharmacology
• International Journal of Biological Sciences
• International Journal of Molecular Sciences
• Nature and Science of Sleep
• Journal of Neurorestoratology
• Eye and Brain
• Neural Regeneration Research
• Brain Research

Professional Societies
• American Association of Anatomists (AAA) (2011-present)
• Sigma Xi (2012-present)
• Society for Neuroscience (2011-present)


Publications


1. Xu XB, Walker CL, Lu Q, Wu W, Eddelman DB, Parrish JM, Xu XM. (2016) RhoA/Rho Kinase
Mediates Neuronal Death Through Regulating cPLA2 Activation. Molecular Neurobiology,
doi:10.1007/s12035-016-0187-6.

2. Walker CL, Zhang YP, Liu, Y, Li, YP, Walker, MJ, Liu, NK, Shields CB, Xu XM. (2016) Anatomicaland functional effects of lateral cervical hemicontusion in adult rats. Restorative Neurology and Neuroscience, 34(3): 389-400.

3. Jones KJ, Lovett-Racke AE, Walker CL, Sanders VM. (2015) CD4 + T Cells and Neuroprotection:Relevance to Motoneuron Injury and Disease. J Neuroimmune Pharmacol. 2015 Jul 7. [Epub ahead of print]

4. Walker, MJ*, Walker CL*, Zhang, YP, Shields, CB, and Xu XM. (2015) Surgical stabilization of the cervical spinal cord for unilateral C5 contusion injury using the NYU/MASCIS impactor. Journal of Visualized Experiments. (95), e50149, doi:10.3791/50149. *, co-first author.

5. Deng, LX, Walker, CL, and Xu, XM. (2015) Schwann Cell-Mediated Axonal Regeneration in the
Central Nervous System, In: Neural Regeneration, So, KF and Xu, XM (eds.) Science Press. In Press.

6. Walker, CL, Wang XF, Bullis, CL, Liu, NK, Lu, QB, Fry, C, Deng, LX, Xu, XM (2015) Biphasic
bisperoxovanadium administration and Schwann cell transplantation for repair after cervical contusive spinal cord injury. Experimental Neurology 264: 163-172. doi: 10.1016/j.expneurol.2014.12.002.

7. Deng, LX, Walker, CL, Xu XM. (2014) Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury. Brain Research. doi:10.1016/j.brainres.2014.09.038.

8. Liu, NK, Zhang, YP, Zou, J, Verhovshek, T, Chen, C, Lu, QB, Walker, CL, Shields, CB, and Xu, XM. (2014) A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus. Brain Research. doi:10.1016/j.brainres.2014.05.042.

9. Li, YP*, Walker, CL*, Zhang, YP, Shields, CB, and Xu, XM. (2014) Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal models studies, and potential future directions of investigation. Frontiers in Biology, 9(2):127–136. doi:10.1007/s11515-014-1297-z. *, co-first author.

10. Walker, CL and Xu XM. (2014) PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury. Neuroscience Letters, 573: 64-68. doi:10.1016/j.neulet.2014.02.039.

11. Walker, CL, Liu, NK, and Xu XM. (2013) The role of PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries. Frontiers in Biology, doi:10.1007/s11515-013-1255-1.

12. Zhang, YP, Walker, MJ, Shields, LBE, Wang, XF, Walker, CL, Xu, XM, and Shields, CB. (2013)
Controlled Cervical Laceration Injury in Mice. Journal of Visualized Experiments (75), e50030,
doi:10.3791/50030.

13. Liu, NK, Zhang, YP, O’Connor, J, Gianaris, A, Ahuja, SK, Oakes, E, Lu, QB, Verhovshek, T,
Walker, CL, Shields, CB Xu, XM. (2012) A bilateral closed-head injury that shows graded brain
damage and behavioral deficits in adult mice. Brain Research, doi:10.1016/j.brainres.2012.12.031.

14. Walker, CL, Walker MJ, Liu, NK, Risberg, EC, Gao, X, Chen, J, and Xu XM. (2012) Systemic
bisperoxovanadium activates Akt/mTOR, reduces autophagy, and promotes recovery after spinal cord injury, PLoS One, doi:10.1371/journal.pone.0030012.

15. Walker, CL and Xu, XM. (2010) Morphological Assessments Following Spinal Cord Injury. In: Animal Models of Acute Neurological Injuries II. Injury and Mechanistic Assessments, In: Contemporary Neuroscience, J Chen, Z Xu, XM Xu, J Zhang (eds). The Humana Press Inc., Totowa NJ.