Richard L. Gregory, PhD

Richard L. Gregory, PhD
Richard L. Gregory, PhD
Interim Associate Dean for Research
Professor of Oral Biology and Pathology and Laboratory Medicine
Adjunct Professor of Preventive and Community Dentistry
Director, PhD. Dental Science Program
Director, Student Research Programs
School of Dentistry

Contact Info

Phone  (317) 274-9949
Fax       (317) 278-1411

Office Address

Indiana University School of Dentistry
Department of Oral Biology
Oral Health Research Institute
415 Lansing St., Room 123
Indianapolis, Indiana  46202


Publications

Select Recent Publications (out of 286 total refereed publications and abstracts):

Xie, D., Y. Weng, X. Guo, J. Zhao, R.L. Gregory and C. Zheng.  2011.  Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions.  Dent. Mat. (in press).

Allam, E., W. Zhang, C. Zheng, R.L. Gregory, and L.J. Windsor.  2011.  Smoking and oral health.  In: Cigarette Smoke Toxicity - Linking Individual Chemicals to Human Diseases.  D. Bernhard (ed.).  Wiley-VCH Verlag GmbH & Co. KGaA  (pub.)  pp. 257-280.

Huang, R., M. Li and R.L. Gregory.  2011.  Bacterial interactions in dental biofilm.  Virulence. (in press).

Weng, Y., X. Guo,J. Zhao, R.L. Gregory and D. Xie. 2010. A PQAS-containing glass-ionomer cement for improved antibacterial function.  J. Biomedical Science and Engineering. 3:956-963.

Xie, D., Y. Weng, X. Guo, J. Zhao, R.L. Gregory and C. Zheng.  2011.  Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions.  Dent. Mat. 27:487-496.

Huang, R., M. Li and R.L. Gregory.  2011.  Bacterial interactions in dental biofilm.  Virulence. (in press).

Gregson, K.S., H. Shih and R.L. Gregory.  2011.  The impact of oral bacteria on the surface and mechanical properties of a dental resin material.  Clin. Oral Invest. (in press).

Nassar, H. and R.L Gregory.  2011.  Effect of honey on Streptococcus mutans growth and biofilm formation.  Appl. Environ. Microbiol. (in press).

Weng, Y., X. Guo, R.L. Gregory and D. Xie. 2010. A novel antibacterial dental glass-ionomer cement.  Eur. J. Oral Sci. 118:531-534.

Sanui, T. and R.L. Gregory. 2009. Analysis of Streptococcus mutans biofilm proteins recognized by salivary immunoglobulin A.  Oral Microbiol. Immunol. 24:361-368.

Fontana M., D. Catt, G.J. Eckert, S. Ofner, M. Toro, R.L. Gregory, A. Ferreira Zandona, H. Eggertsson, R. Jackson, J. Chin, D. Zero and C. Sissons. 2009. Xylitol: effects on the acquisition of cariogenic species in infants.  J. Ped. Dent. 31:257-266.

Koh, I-W., Y. Oshida, C.J. Andres and R.L. Gregory.  2008. Effect of surface area ratios and bacteria on electrochemical behavior of galvanically coupled titanium.  Int. J. Prosthodont. 21:433-436.

Catt, D.M. and R.L. Gregory. 2005. Streptococcus mutans murein hydrolase.  J. Bact. 187:7863-7865.

Fugaro, O.J., J.O. Fugaro, B. Matis, R.L. Gregory, M.A. Cochran and I.A. Mjor. 2005. The dental pulp: inflammatory markers and vital bleaching. Am. J. Dent. 18:229-232.

Olson, B.L., N.A. Warner, R.L. Gregory, J.L. McDonald and C.A. Zapata. 2005. Periodontal ligament fibroblast interleukin-6 release after exposure to nicotine. Oral Biosciences Med. 2:15-19.

Ge, J., D.M. Catt and R.L. Gregory. 2004. Streptococcus mutans surface a-enolase binds salivary MG2 and human plasminogen. Infect. Immun. 72:6748-6752.

Chang, J-C., Y. Oshida, R.L. Gregory, C.J. Andres, T.M. Barco and D. Brown. 2003. Electrochemical study on microbiology-related corrosion of metallic materials.  Bio-Med. Mater. Eng. 13:281-295.

Dowling, J.S., M. Hockenberry and R.L. Gregory. 2003. Sense of humor, childhood cancer stressors, and outcomes of psychosocial adjustment, immune function, and infection. J. Ped. Oncol. Nursing 20:271-292.

Wood, K.L., P. Chaiyarit, R.B. Day, Y. Wang, C.T. Schnizlein-Bick, R.L. Gregory and H.L. Twigg III. 2003. Measurements of HIV viral loads from different levels of the respiratory tract. Chest 124:536-542.

Gonzalez-Cabezas, C., Y. Li, R.L. Gregory and G.K. Stookey.  2002  Distribution of cariogenic bacteria in carious lesions around resin restorations.  Amer. J. Dent. 15:248-251.

Sanders, B.J.,Gregory, R.L., K. Moore and D.R. Avery. 2002. Antibacterial and physical properties of resin modified glass-ionomers combined with chlorhexidine. J. Oral Rehabilitation 29:553-558.

Gregory, R.L. 2001. Modified immunogenicity of a mucosally administered antigen. Clin. Diagn. Lab. Immunol. 8:540-544.

 Ge, J., Catt, D.M.,  and Gregory, R.L.   2004.  Streptococcus mutans surface α-enolase binds salivary MG2 and human plasminogen.  Infect. Immun. 72:6748-6752. 

Chang, J-C., Oshida, Y., Gregory, R.L., Andres, C.J., Barco, T.M. and Brown, D.  2003. Electrochemical study on microbiology-related corrosion of metallic materials.   Bio-Med. Mater. Eng. 13:281-295.

Dowling, J.S., Hockenberry, M., and Gregory, R.L.  2003.  Sense of humor, childhood cancer stressors, and outcomes of psychosocial adjustment, immune function, and infection.  J. Ped. Oncol.  Nursing 20:271-292.

Ge, J., Catt, D.M.,  and Gregory, R.L.   2004.  Streptococcus mutans surface α-enolase binds salivary MG2 and human plasminogen.  Infect. Immun. 72:6748-6752. 

Chang, J-C., Oshida, Y., Gregory, R.L., Andres, C.J., Barco, T.M. and Brown, D.  2003. Electrochemical study on microbiology-related corrosion of metallic materials.   Bio-Med. Mater. Eng. 13:281-295.

Dowling, J.S., Hockenberry, M., and Gregory, R.L.  2003.  Sense of humor, childhood cancer stressors, and outcomes of psychosocial adjustment, immune function, and infection.  J. Ped. Oncol.  Nursing 20:271-292.

Wood, K.L., Chaiyarit, P., Day, R.B., Wang, Y., Schnizlein-Bick, C.T., Gregory, R.L. and Twigg III, H.L. 2003.  Measurements of HIV viral loads from different levels of the respiratory tract.  Chest 124:536.542.

Sanders, B.J., Gregory, R.L., Moore, K. and Avery, D.R. 2002. Antibacterial and physical properties of resin modified glass-ionomers combined with chlorhexidine. J. Oral Rehabilitation 29:553-558.

Gonzalez-Cabezas, C., Li, Y., Gregory, R.L. and Stookey, G.K.  2002  Distribution of cariogenic bacteria in carious lesions around resin restorations.  Amer. J. Dent. 15:248-251.

Toro, M.J., Escalona, L., Chaiyarit, P., Warner, N.A., and Gregory, R.L.  2001.  Salivaryimmunoglobulin A antibodies togp41 in human immunodeficiency virus-seropositive patients: lack of correlationwith diseaseprogression.  Oral Microbiol. Immunol.  16:188-192.

Gregory, R. L.  2001. Evidence of modified immunogenicity of a mucosally administered antigen.  Clin. Diagn. Lab. Immunol.  8:540-544. 

Fontana, M., Buller, T.L., Dunipace, A.J., Stookey, G.K., and Gregory, R.L.  2000.  An in vitromicrobial-caries model used to study the efficacy of antibodies to Streptococcusmutans surface proteins in preventingdental caries.  Clin. Diagn. Lab. Immunol.  7:49-54.

Escalona, L.A., Warner, N.A.,Toro, M., and Gregory, R.L.  1999.  IgA antibodies to Escherichiacoli in saliva frompatients with HIV infection.  Acta. Odontologica Venezolana. 37:11-16.

Gonzalez-Cabezas, C., Li, Y.,Gregory, R.L., and Stookey, G.K.  1999.  Distribution of threecariogenic bacteria insecondary carious lesions around amalgam restorations.  Caries Res. 33:357-365.

Chaiyarit, P., Kafrawy, A.H.,Miles, D.A., Zunt, S.L., Van Dis, M.L., Gregory, R.L.  1999.  Orallichen planus: animmunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs)and a unifyinghypothesis of pathogenesis. J. Oral Pathol. Med.  28:210-215.

Fontana, M., Dunipace, A.J., Stookey, G.K., and Gregory, R.L.  1999.  Intranasal immunizationagainst dental carieswith Streptococcus mutans enriched fimbrial preparation.  Clin. Diagn. Lab. Immunol.  6:405-409.

Ray, C.A., Gfell, L.E., Buller, T.L., and Gregory, R.L.  1999.  Interactions of Streptococcusmutans fimbria-associatedsurface proteins with salivary components.  Clin. Diagn. Lab. Immunol6: 400-404.

Pascale, J.M., Shaw, M.M., Durant, P.J., Amador, A.A., Bartlett, M.S., Smith, J.W., Gregory, R.L., and  McLaughlin, G.L. 1999.   Intranasal immunization confers protection againstmurine Pneumocystis carniiinfection.  Infect. Immun. 67: 805-809.

Gregory, R.L., Rahman, A.M.A., andAvery, D.R.  1998.  Effect of restorative treatment on mutans streptococciand IgA antibodies.  Ped. Dent.  20: 273-277.

Moore, M.A., Gregory, R.L., Switalski, L., Hakki, Z.W., Gfell, L.E., and Kowolik, M.J.  1998.  Differential activation ofhuman neutrophils by Streptococcus mutans isolates from root surfacelesions and caries free andcaries active subjects.  Oral Microbiol. Immunol.  13:41-46.

Moore, M.A., Hakki, Z.W., Gregory, R.L., Gfell, L.E., Kim-Park, W.K., Kowolik, M.J.  1997.  Influence of heat inactivation of human serum on the opsonization of Streptococcus mutans.  In:  Phagocytes: Biology, Physiology, Pathology and Pharmacotherapeutics.  Annals of the New York Academy of Science,  832:383.393.

Gregory, R.L., Wallace, J.P., Gfell, L.E., Marks, J., and King, B.A.  1997.  Effect of exerciseon milkimmunoglobulin A levels.  Med. Sci. Sports Exerc.  29:1596-1601. Pascale, J.M., Isaacs, M.D.,Contreras, P., Gomez, B., Lozano, L., Austin, E., de Martin, M.C., Gregory, R.L.,McLaughlin, G.L., and Amador, A.  1997.  Immunologicalmarkers of disease progression in patients infected withthe human immunodeficiency virus.  Clin. Diagn Lab. Immunol. 4:474-477.

Perrone, M., Gfell, L.E.,Fontana, M., and Gregory, R.L.  1997.  Antigenic characterization offimbriae preparationsfrom Streptococcus mutans isolates from caries-free and cariessusceptible subjects.  Clin. Diagn. Lab. Immunol. 4: 291-296.

 

 

Research Interests

Dr. Gregory's research has been funded by grants from the National Institute of Dental and Craniofacial Research, National Institute of Heart and Lung, Smokeless Tobacco Research Council and numerous industrial projects.  Current efforts are focused on mucosal biofilm biology with specific interests in oral bacteria, particularly Streptococcus mutans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans.  To help understand the complex biofilm interactions in Streptococcus mutans-induced caries formation, we are defining the role bacterial cell surface proteins play in colonization and bacterial atherosclerosis/endocarditis. Mechanisms that may diminish colonization of S. mutans cells to enamel surfaces and cardiac tissue are being explored. The effect of tobacco on S. mutans virulence is a major focus.  Inhibitory factors being investigated include botanical agents, mucosal vaccines and neutralization of receptor sites.  A sensitive and specific in vitro biofilm caries model system has been developed in this laboratory and is being used to assess the ability of various anti-microbial agents and antibodies in prevention of S. mutans colonization of enamel surfaces and caries formation. In addition, the model is used to determine the relative cariogenicity of oral microorganisms.  His work is currently supported by NIH U01 and RC1 grants.