L. Jack Windsor, Ph.D.

L. Jack Windsor, Ph.D.
L. Jack Windsor, Ph.D.

Associate Professor of Oral Biology
Adjunct Associate Professor of Anatomy and Cell Biology
School of Medicine
Director, Tobacco Cessation and Biobehavioral Signature Center


Contact Info

(317) 274-1448 (Phone)
(317) 278-1411 (Fax)

Office Address

Indiana University School of Dentistry
Department of Oral Biology
1121 W. Michigan Street, Room  271
Indianapolis, Indiana 46202


Publications

Papers Published in Refereed Journals

Bottino, M. C., Batarseh, G., Palasuk, J., Windsor, L. J., and Platt, J. A.: Nanaotube-Modified Dentin-Adhesive-Physicochemical and Dentin Bonding Characterizations, Dental Materials, submitted.

Bottino, M. C., Yassen, G. H., Platt, J. A., Labban, N., Windsor, L. J., and Spolnik, K. J.:A novel three-dimensional scaffold for regenerative endodontics: materials and characterizations, J Tissue Eng. Regen. Med., in press.

Allam, E., Eleniste, P., Bruzzaniti, A., and Windsor, L. J.: Osteoblast functions and their role in skeletal bone diseases. In: Osteoblasts: Morphology, Functions and Clinical Implications. Scheurer, NY: Nova Science Publishers Inc., 2013.

Allam, E., Bottino, M., Al-Shibani, N., and Windsor, L. J.: Collagen scaffolds: tissue engineering and repair. In: Type I Collagen: Biological Functions, Synthesis and Medicinal Applications. Hauppauge, NY: Nova Science Publishers Inc., 2012.

Allam, E., DelaCruz, K., Ghonemima, A., Sun, J., and Windsor, L. J.: Effects of Tobacco on cytokine expression from human endothelial cells, Oral Diseases, 2012, doi:10.1111/odi.12050.

Kamal, A., Allam, E., Dehis, M., Zunt, S., and Windsor, L. J.: Assessment of changes to the dental follicle in deep and partially impacted mandibular third molar, The Egyptian Ass. Oral and Maxillofacial Surgeons, Vol. 3, Number 1: 30-35, 2012.

Batarseh, G., Labban, L., Liu, Y., Gregson, K. G., and Windsor, L. J: TEGDMA induction of apoptotic proteins in pulp fibroblasts, submitted, 2012.

Borzangy, S., Labban, N., and Windsor, L. J.: Effects of Provision Acrylic Resins on the Expression of Cytokines/Growth Factors from Epithelial Cells and on Collagen Degradation, J Prosthet. Dent., submitted, 2012.

Sun, J., Song, F., Zhang, W., Sexton, B. E., and Windsor, L. J.: Effects of alendronate on human osteoblast-like MG63 cells and matrix metalloproteinases, Archives of Oral Biology, 57: 728-736, 2012.

Saini, P., Al-Shibani, N., Sun, J., Zhang, W., Song, F., Gregson, K., and Windsor, L. J.:   Effects of Calendula officinalis on Human Gingival Fibroblasts, Homeopathy, 101: 92-98 2012.

Ghoneima A, Allam E, Kula K, and Windsor J. Three-dimensional (3D) Imaging and Software Advances in Orthodontics: Orthodontics- Basic Aspects and Clinical Considerations, Editor: Farid Bourzgui, pp. 177-194, InTech  2011.

Windsor
, L. J. and Steele, D. L.: Expression of recombinant matrix metalloproteinases in Escherichia coli, Matrix Metalloproteinases 2nd edition, Methods in Molecular Biology, 67-81, 2011.

Al-Shibani, N., Labban, N., Allam, E., and Windsor, L. J.: Chapter: Tobacco: A Risk Factor for Periodontal Disease, Periodontal Disease: Symptoms, Treatment and Prevention, Editor: Sho L. Yamamoto, pp.121-135. Nova Science Publishers, 2011

Allam, E., Zhang, W., Zheng, C., Gregory, R. L., and Windsor, L. J.: Chapter 13: Smoking and Oral Health, Cigarette Smoke Toxicity: Linking Individuals Chemicals to Human Diseases, David Bernhard, Wiley_VCH Verlag GmbH &Co., KGaA, Weiheim, 2010.

Allam, E., Zhang, W., Sun, S., Labban, N., Song, F., and Windsor, L. J Effects of Cigarette Smoke Condensate on Oral Squamous Cell Carcinoma Cells, Archives of Oral Biology 2011, doi:10.1016/j.archoralbio.

Al-Shibani, N., Labban, N., Kowolik, M. J., Ruby, J., Categories: and Windsor, L. J.: The Response of Human Neutrophils to Nicotine and/or Porphyromonas gingivalis, J. Periodont. Res DOI: 10.1902/jop.2011.100757, 2011.

Zhang, W., Fang, M., Song, F., and Windsor, L. J.: Effects of cigarette smoke condensate and nicotine on human gingival fibroblast-mediated collagen degradation, J Periodontal Res 82(7):1071-9, 2011.

Santosh, N., Windsor, L. J., Mahmoudi, B. S., Li, B., Zhang, W., Chernoff, E. A., Rao, N., Stocum, D. L., and Song, F.: Matrix metalloproteinase expression during blastema formation in regeneration-competent versus regeneration-deficient amphibian limbs, Dev Dyn. 240(5):1127-41, 2011.

Allam, E., Allen, M. R. Chu, T. M., Ghoneima, A., and Windsor, L. J.: In vivo effects of             zoledronic acid on oral muscosal epithelial cells, Oral Diseases, 17, 291–297, 2011.

Zhang, W., Song, F., and Windsor, L. J.: Effects of Tobacco and P. gingivalis on gingival  fibroblasts, J Dental Res., 89:527-531, 2010.

Allam, E., Draz, A., Hassan, A., Neamat, A., Galal, M., and Windsor, L. J.: RANKL Expression in Ligature-Induced Periodontitis in Osteoporotic and Nonosteoporotoc Rats, J. Periodont. Res., 45:136-142, 2010.

Zhang, W., Song, F., and Windsor, L. J.: Cigarette smoke condensate affects the collagen-degrading ability of human gingival fibroblasts, J Periodontal Res., 44:704-713,  2010.

Gregson, K. S., Windsor, L. J., and Platt, J. A.: Biodegradation of a dental resin  material by  fibroblast conditioned media, Dent. Mater., 25:1358-1362, 2009.

Ghoneima, A. A., Allam, E. S., Zunt, S. L., and Windsor, L. J.: Bisphosphonate treatment and orthodontic considerations, Orthod. Craniofac. Res., 12:1-10, 2009.

Gregson, K., O’Neill, J. T., Platt, J. A., and Windsor, L. J.: In vitro induction of hydrolytic activity in human gingival and pulp fibroblasts by triethylene glycol dimethacrylate and monocyte chemotatic protein-1, Dent. Mater., 24:1461-1467, 2008.

Labban, N., Song, F., Andres, C., Platt, J., Al-Shibani, N., and Windsor, L. J.: Effects of provisional acrylic resins on gingival fibroblast cytokine/growth factor expression, Int. J. Prosthodont., 100:390-397, 2008.

Al-Shibani, N., and Windsor, L. J.: Effects of Porphyromonas gingivalis on human gingival fibroblasts from healthy and inflamed tissues, J. Periodont. Res., 43:465-470, 2008.

Chen, Y., Zhang, W., Geng, N., Tian, K., and Windsor, L. J.: MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus, Head & Neck, 30:1237-1245, 2008.

Almasri, A., Wisithphrom, K., Windsor, L. J., and Olson, B. L.: Nicotine and lipopolysaccharide affect cytokine expression from gingival fibroblasts, J. Periodontol, 78:533-541, 2007.

Ellis, M., Song, F., Parks, E. T., Eckert, G. J., Dean, J. A., and Windsor, L. J.: An evaluation of DNA yield, DNA quality and bite registration from a dental impression wafer, JADA, 138:1234-1240, 2007.

Zhou, J., Olson, B. L., and Windsor, L. J.: Nicotine increases the collagen-degrading ability of human gingival fibroblasts, J. Periodont. Res., 42:228-235, 2007.

Zhou, J. and Windsor, L. J.: Heterogeneity in the collagen-degrading ability of Porphyromonas gingivalis-stimulated human gingival fibroblasts, J. Periodont. Res., 42:77-84, 2007.

Song, F., Bergdoll, A. S., and Windsor, L. J.: Temporomandibular joint synovial fibroblasts mediate serine proteinase dependent Type I collagen degradation, Biochim. Biophys. Acta, 1760:1521-1528, 2006.

Wisithphrom, K. and Windsor, L. J.: The effects of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and transforming growth factor-beta1 on pulp fibroblast mediated collagen degradation, J. Endod., 32:853-861, 2006.

Song, F., Wisithphrom, K., Zhou, J., and Windsor, L. J.: Matrix metalloproteinase dependent and independent collagen degradation, Front. Biosci., 11:3100-3120, 2006.

Wisithphrom, K., Murray, P. E., About, I. A., and Windsor, L. J.: Interactions between cavity preparation and restoration events and their effects on pulp vitality, Int. J. Peridontics Restorative Dent., 26:596-605, 2006.

Wisithphrom, K. and Windsor, L. J.: Interleukin-1 alpha alters the expression of matrix metalloproteinases and collagen degradation by pulp fibroblasts, J. Endod., 32:186-192, 2006.

Zhou, J. and Windsor, L. J.: Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases, J. Periodont. Res., 41:47-54, 2006.

Song, F. and Windsor, L. J.: Novel nonmatrix-metalloproteinase-mediated collagen degradation, Biochim. Biophys. Acta, 1721:65-72, 2005.

Murray, P. E., Windsor, L. J., Hafez, A. A., Stevenson, R. G., and Cox, C. F.: Comparison of pulp responses to resin composites, Operative Dentistry, 28: 242-250, 2003.

Murray, P. E., Smith, A. J., Windsor, L. J., and Mjör, I. A.: Remaining dentine thickness and human pulp responses, International Endodontic Journal, 36(1): 33-43, 2003.

Murray, P. E., About, I. A., Franquin, J-C., and Windsor, L. J.: Odontoblast morphology and dental repair, Journal of Dentistry, 31: 75-82, 2003.

Behzadian, M. A., Windsor, L. J., Ghaly, N., Liou, G., Tsai, N., and Caldwell, R. B.: VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor, FASEB Journal, 17: 752-754, 2003.

Murray, P. E., Hafez, A. A., Smith, A. J., Windsor, L. J., and Cox, C. F.: Histomorphometric analysis of odontoblast-like cell numbers and dentine bridge secretory activity following pulp exposure, International Endodontic Journal, 36(2): 106-116, 2003.

Murray, P. E., Kitasako, Y., Windsor, L. J., Tagami, J., and Smith, A. J.: Hierarchy of variables correlated to odontoblast-like cell numbers following pulp capping.  Journal of Dentistry, 30: 297-304, 2002.

Murray, P. E., Hafez, A. A., Windsor, L. J., Smith, A. J., and Cox, C. F.: Comparison of pulp responses following restoration of exposed and non-exposed cavities, Journal of Dentistry, 30: 213-222, 2002.

Murray, P. E., Windsor, L. J., Smyth, T. W., Hafez, A. A., and Cox, C. F.: Analysis of pulpal reactions to restorative procedures, materials, pulp capping, and future therapies. Criticial Reviews in Oral Biology and Medicine, 13: 509-520, 2002.

Hantke, B., Lahmann, C., Venzke, K., Fischer, T., Kocourek, A., Windsor, L. J., Bergemann, J., Stab, F., and Tschesche, H.: Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation, J. Photochem. and Photobiol. Sciences, 1: 826-833, 2002.

Windsor, L. J., Havemose-Poulsen, A., Yamada, S., Lyons, J. G., Birkedal-Hansen-Hansen, B., Stetler-Stevenson, W., and Birkedal-Hansen, H.: Matrix Metalloproteinases, Current Protocols in Cell Biology, Supplement 13, Unit 10.8, 2002.

Aznavoorian, S., Moore, B. A., Alexander, L. D., Hallit, S., Windsor, L. J., and Engler, J. A.: Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells, Cancer Research, 61: 6264-6275, 2001.

Behzadian, M. A., Wang, X., Windsor, L. J., Ghaly, N., and Caldwell, R. B.: TGF-beta increases retinal endothelial cell permeability by increasing MMP-9: possible role of glial cells in endothelial barrier function, Invest. Ophthalmol. Vis. Sci., 42: 853-859, 2001.

Saghizadeh, M., Brown, D. J., Castellon, R., Chwa, M., Huang, G. H., Ljubimova, J. Y., Rosenberg, S., Spirin, K. S., Stolitenko, R. B., Adachi, W., Kinoshita, S., Murphy, G., Windsor, L. J., Kenney, M. C., and Ljubimov, A. V.: Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations, Am. J. Pathol., 158: 723-734, 2001.

Windsor, L. J. and Steele, D. L.: Expression of recombinant matrix metalloproteinases in Escherichia coli, Methods in Molecular Biology, 151: 191-205, 2001.

Moore, B. A., Arnavoorian, S., Engler, J. A., and Windsor, L. J.: Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts, Biochim. Biophys. Acta, 1502: 307-318, 2000.

Steele, D. L., El-Kabbani, O., Dunten, P., Windsor, L. J., Kammlott, R.U., Crowther, R. LC., Michoud, C.,  Engler, J. A., and Birktoft, J. J.: Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1, Protein Engineering, 13(6):  397-405, 2000.

Pickett, K. L., Harber, G. J., DeCarlo, A. A., Louis, P., Shaneyfelt, S., Windsor, L. J., and Bodden, M. K.: 92K-GL (MMP-9) and 72K-GL (MMP-2) are produced in vivo by human oral squamous cell carcinomas and can enhance FIB-CL (MMP-1) activity in vitro, J. Dent. Res.,  78: 1354-1361, 1999.

Galazka, G., Windsor, L. J., Birkedal-Hansen, H., and Engler, J. A.: Spontaneous propeptide processing of mini-stromelysin-1 mutants blocked by APMA ((4-Aminophenyl)mercuric acetate), Biochemistry, 38: 1316-1322, 1999.

Qin, H., Moellinger, J. D., Wells, A., Windsor, L. J., Sun, Y., and Benveniste, E. N.: Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-alpha and IFN-gamma, J. Immunol., 161: 6664-6673.

DeCarlo Jr., A. A., Grenett, H. E., Harber, G. J., Windsor, L. J., Bodden, M. K., Birkedal-Hansen, B., and Birkedal-Hansen, H.: Induction of matrix metalloproteinases and a collagen-degrading phenotype in fibroblasts and epithelial cells by secreted Porphyromonas gingivalis proteinase, J. Peridont. Res., 33: 408-420,1998.

Caterina, N. C. M., Windsor, L. J., Bodden, M. K., Yermovsky, A. E., Birkedal-Hansen, H., and Engler, J. A.: Glycosylation and NH2-terminal domain mutants of the tissue inhibitor of metalloproteinases-1 (TIMP-1), Biochim. Biophys. Acta, 1388: 21-34,1998.

Birkedal-Hansen, H., Bodden, M. K., Caterina, N. C. M., Windsor, L. J., Netzel-Arnett, S., and Engler, J. A.: In Inhibitors of Metalloproteinases in Development and Disease (Hawkes, S. P., Edwards, D. R., and Khokha, R., Eds) Harwood Acedemic Publishing, Lausanne, Switzerland, 1998.

DeCarlo Jr., A. A., Windsor, L. J., Bodden, M. K., Harber, G. J., Birkedal-Hansen, B., and Birkedal-Hansen, H.: Activation and novel processing of matrix metalloproteinases by a thiol-proteinase from the oral anaerobe Porphyromonas gingivalis, J. Dent. Res. 76: 1260-1270,1997.

Windsor, L. J., Steele, D. L., LeBlanc, S. B., and Taylor, K. B.: Catalytic domain comparisons of human fibroblast-type collagenase, stromelysin-1, and matrilysin, Biochim Biophys. Acta, 1334: 261-272, 1997.

Caterina, N. C. M., Windsor, L. J., Yermovsky, A. E., Bodden, M. K., Taylor, K. B., Birkedal-Hansen, H., and Engler, J. A.: Replacement of conserved cysteines in human tissue inhibitor of metalloproteinases-1, J. Biol. Chem., 272: 32141-32149, 1997.

Galazka, G., Windsor, L. J., Birkedal-Hansen, H., and Engler, J. A.: APMA (4-aminophenylmercuric acetate) activation of stromelysin-1 involves protein interactions in addition to those with cysteine-75 in the propeptide, Biochemistry, 35: 11221-11227, 1996.

Taylor, K. B., Windsor, L. J., Caterina, N. C. M., Bodden, M. K., and Engler, J. A.: The mechanism of inhibition of collagenase by TIMP-1, J. Biol. Chem., 271: 23938-23945, 1996.

Sang,Q.-X, Bodden, M. K., and Windsor, L. J.: Activation of human progelatinase A by collagenase and matrilysin: activation of procollagenase by matrilysin, J. Protein Chem., 15: 243-253, 1996.

Bodden, M. K., Windsor, L. J., Caterina, N. C. M., Harber, G. J., Birkedal-Hansen, B., and Birkedal-Hansen, H.: Human TIMP-1 binds to pro-M(r) 92K GL (gelatinase B, MMP-9) through the "second disulfide knot", Annals NY Acad. Sci., 732: 403-408, 1994.

Bodden, M. K., Windsor, L. J., Caterina, N. C. M., Yermovsky, A., Birkedal-Hansen, B., Galazka, G., Engler, J. A., and Birkedal-Hansen, H.: Analysis of the TIMP-1/FIB-CL complex, Annals NY Acad. Sci., 732: 84-96, 1994.

Bodden, M. K., Harber, G. J., Birkedal-Hansen, B., Windsor, L. J., Caterina, N. C. M., Engler, J. A., and Birkedal-Hansen, H.: Functional domains of human TIMP-1 (tissue inhibitor of metalloproteinases), J. Biol. Chem., 269: 18943-18952, 1994.

Windsor, L. J., Bodden, M. K., Birkedal-Hansen, B., Engler, J. A., and Birkedal-Hansen, H.: Mutational analysis of residues in and around the active site of human fibroblast-type collagenase, J. Biol. Chem. 269: 26201-26207, 1994.

Windsor, L. J., Grenett, H., Birkedal-Hansen, B., Bodden, M. K., Engler, J. A., and Birkedal-Hansen, H.: Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters, J. Biol. Chem., 268: 17341-17347, 1993.

Birkedal-Hansen, H., Moore, W. G. I., Bodden, M. K., Windsor, L. J., Birkedal-Hansen, B., DeCarlo, A., and Engler, J. A.: Matrix metalloproteinases: a review, Crit. Rev. Oral Biol. Med. 4:197-250, 1993.

Birkedal-Hansen, B., Lyons, J. G., Windsor, L. J., Pierson, M., Moore, W. G. I., and Birkedal-Hansen, H.: Strategies for production of inhibitory monoclonal antibodies against matrix-degrading proteinases.  In Matrix Metalloproteinases and Inhibitors, (H. Birkedal-Hansen, Z. Werb, H. Welgus, & H. Van Wart, Eds.), Matrix, Special Supplement #1; Fischer Verlag, Stuttgart, 1992; pp. 328-329.

Engler, J. A., Windsor, L. J., Birkedal-Hansen, B., and Birkedal-Hansen, H.: The latency of the human fibroblast collagenase precursor depends on an internal cysteine residue.  In Matrix Metalloproteinases and Inhibitors,  (H. Birkedal-Hansen, Z. Werb, H. Welgus, & H. Van Wart, Eds.), Matrix, Special Supplement #1; Fischer Verlag, Stuttgart, 1992; pp. 231-236.

Birkedal-Hansen, H., Lin, H. Y., Wells, B. R., Birkedal-Hansen, B., Windsor, L. J., and Pierson, M.: Degradation of collagen fibrils by live cells: role of expression and activation of procollagenase. In Matrix Metalloproteinases and Inhibitors, (H. Birkedal-Hansen, Z. Werb, H. Welgus, & H. Van Wart, Eds.), Matrix, Special Supplement #1; Fischer Verlag, Stuttgart, 1992; pp. 368-374.

Windsor, L. J., Birkedal-Hansen, H., Birkedal-Hansen, B., and Engler, J. A.: An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase, Biochemistry 30: 641-647, 1991.

Fields, G. B., Netzel-Arnett, S. J., Windsor, L. J., Engler, J. A., Birkedal-Hansen, H., and Van Wart, H. E.: Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active site, Biochemistry 29: 6670-6677, 1990.

Birkedal-Hansen, H., Birkedal-Hansen, B., Windsor, L. J., Lin, H. Y., Taylor, R. E., and Moore, W. G. I.: Use of inhibitory (anti-catalytic) antibodies to study extracellular proteolysis, Immunol. Invest. 18: 211-224, 1989.