James K. Hartsfield Jr, DMD, PhD, FACMG

James K. Hartsfield Jr, DMD, PhD, FACMG
James K. Hartsfield Jr, DMD, PhD, FACMG

Adjunct Professor of Orthodontics, IU School of Dentistry
Adjunct Professor of Medical & Molecular Genetics, IU School of Medicine


Contact Info

Office Address

Background

Dr. Hartsfield received his D.M.D. from the Medical University of South Carolina. Following a medical genetics fellowship resulting in an M.S. degree from Indiana University, Dr. Hartsfield studied orthodontics for three years at Harvard University. During this time he began research in the causes of oral and facial defects as a research fellow in pediatrics at the Massachusetts General Hospital, receiving from Harvard his certificate in orthodontics and a Master of Medical Science degree. 

Following a postdoctoral fellowship in medical genetics at the University of South Florida (U.S.F.) College of Medicine in Tampa, Dr. Hartsfield became an Assistant Professor in the Department of Pediatrics at U.S.F. There he received a Physician Scientist Award from the National Institutes of Health, which supported his continued studies into the causes of birth defects leading to a Ph.D. degree from the U.S.F. College of Medicine. 

Dr. Hartsfield is a Founding Fellow in the American College of Medical Genetics and a Diplomate of the American Board of Medical Genetics. He is also a Diplomate of the American Board of Orthodontics, and a Fellow in the College of Diplomates of the American Board of Orthodontics. Dr. Hartsfield is a Fellow in the American College of Dentists, and the International College of Dentists. He was elected Vice President of the International Association for Dental Research Craniofacial Biology Group in 2003, serving as the group President-Elect and Group Program Chairman for 2004-2005, and President for 2005-2006. Dr. Hartsfield is the Vice-President of the Harvard Society for the Advancement of Orthodontics. He is a member of the Board of Directors for the Conferences on Orthodontic Advances in Science and Technology. 

Dr. Hartsfield received the American Association of Orthodontists Foundation 2001 B.F. Dewell Memorial Biomedical Research Award, and was the research mentor of a Ph.D./Orthodontic student who received the 2002 Henry Sicher First Research Essay Award from the American Association of Orthodontists for the study of a genetic factor that influences the risk of external apical root resorption during orthodontic treatment; and, who received the 2007 Beni Solow Award for the most outstanding paper published during 2006 in the European Journal of Orthodontics. 

Dr. Hartsfield has been a reviewer for 24 different dental and medical journals. He is on the editorial board of the Journal of Dental Research, and is a review board member of the International Journal of Oral & Maxillofacial Implants. He was the guest editor in 2008 for the Seminars in Orthodontics volume on Genetics in Orthodontics. 

Dr. Hartsfield’s activity in the department is primarily through research collaboration and co-mentoring of students. 

Publications

Papers Published in Refereed Journals

Sheppard G, JK Hartsfield Jr, J Kowolik, S Ofner, M Peacock, L DiMeglio: The Effects of Osteogenesis Imperfecta and Bisphosphonate Therapy on Dental Development. In preparation for submission. 

Morrison MW, JK Hartsfield Jr, TM Foroud, WE Roberts: Relative Risk of Class II Division 2 Malocclusion in First-Degree Relatives of Probands With Class II Division 2 Malocclusion. Submitted to Angle Orthod. 

Crane CL, JK Hartsfield Jr, S Ofner, FE Eraso: Association of Marginal Ridge Discrepancies and Root Angulation Errors Using the American Board of Orthodontics Objective Grading System. Submitted to Angle Orthod. 

Ortenzio RM, WE Roberts, JT Watson , GJ Eckert, JK Hartsfield Jr: Comparison of Facial and Dental Ethnic Traits for Assessing Orthodontic Patient Ancestry. Submitted to Angle Orthod. 

Viecilli RF, TR Katona, J Chen, JK Hartsfield Jr, WE Roberts Jr: Orthodontic mechanotransduction and the role of the P2X7 receptor. Submitted to Am J Orthod Dentofacial Orthop. 

Chen S, JK Hartsfield Jr, WE Roberts: Biological Aspects of Bone Growth and Metabolism in Orthodontics. Biological Mechanisms of Tooth Movement. eds. V Krishnan and Z Davidovitch, Wiley-Blackwell Publishing, Oxford, UK, in press. 

Viecilli RF, T.R. Katona, Chen J, JK Hartsfield Jr, Roberts WE: Comparison of dentoalveolar morphology in WT and P2X7R KO mice for the development of biomechanical orthodontic models. Anat Rec, in press. 

Chien PC, ET Parks, F Eraso, JK Hartsfield Jr, WE Roberts: Comparison of reliability in anatomic landmarks identification utilizing two-dimensional digital cephalometrics and three-dimensional cone beam computed tomography in vivo. J Dentomaxillofacial Radiol, in press. 

Park Y, JK Hartsfield Jr, TR Katona, WE Roberts: Tooth Positioner Effects on Occlusal Contacts and Treatment Outcomes. Angle Orthod, in press. 

Abass S, JK Hartsfield Jr, R Al-Qawasmi, ET Everett, T Foroud, WE Roberts: Inheritance of Susceptibility to Root Resorption Associated with Orthodontic Force in Mice. Am J Orthod Dentofacial Orthop, in press. 

McKnight DA, PS Hart, TC Hart, JK Hartsfield Jr, A Wilson, JT Wright, LW Fisher: A comprehensive analysis of normal variation and disease causing mutations in the human DSPP gene. Hum Mutat 0:1-13;2008 [Epub ahead of print]. 

Viecilli RF, TR Katona, J Chen, JK Hartsfield, WE Roberts: The three-dimensional mechanical environment of orthodontic tooth movement and root resorption. Am J Orthod Dentofacial Orthop 133:791.e11-791.e26;2008. 

Hartsfield JK Jr: Personalized Orthodontics, The Future of Genetics in Practice Semin Orthod 14:166-171;2008. 

Sprowls MW, RE Ward, PL Jamison, JK Hartsfield Jr: Dental Arch Asymmetry, Fluctuating Dental Asymmetry and Dental Crowding: A Comparison of Tooth Position and Tooth Size Between Antimeres. Semin Orthod 14:157-165;2008. 

Abass SK, JK Hartsfield Jr: Investigation of Genetic Factors Affecting Complex Traits Using External Apical Root Resorption as a Model. Semin Orthod 14:115-124;2008. 

Cruz R, H Keirger, R de Godói Mattos Ferreira, J Mah, J Hartsfield Jr, S Oliveira: Major gene and multifactorial inheritance of mandibular prognathism. Am J Med Genet Part A 146A:71–77;2008.

Vu C, WE Roberts, JK Hartsfield Jr, S Ofner: Treatment complexity index for assessing the relationship of treatment duration and outcomes in a graduate orthodontics clinic. Am J Orthod Dentofacial Orthop 133:9.e1-9.e13;2008. 

Abass SK, JK Hartsfield Jr: Orthodontics and External Apical Root Resorption. Semin Orthod 13:246-256;2007. 

Campbell CL, WE Roberts, JK Hartsfield Jr, R Qi: Treatment outcomes in a graduate orthodontic clinic for cases defined by the American Board of Orthodontics malocclusion categories. Am J Orthod Dentofacial Orthop 132:822-829;2007. 

Hartsfield JK: Review of the Etiologic Heterogeneity of the Oculo-Auriculo-Vertebral Spectrum (Hemifacial Microsomia). Orthod Craniofac Res 10:121-128;2007. 

Hartsfield JK Jr, S Schwartz: Dental Care for People with Osteogenesis Imperfecta. Public Information sheet for the Osteogenesis Imperfecta Foundation, Inc, 2007. (http://www.oif.org/site/DocServer/Dental_Care.pdf?docID=7196). 

Knierim K, WE Roberts, JK Hartsfield Jr: Assessing Treatment Outcomes for a Graduate Orthodontics Program: Follow-Up Study for Classes of 2001-2003. American Journal of Orthodontics and Dentofacial Orthopedics, 130:648.el-648.ell;2006. 

Al-Qawasmi RA, JK Hartsfield Jr, ET Everett, LL Flury, L Liu, TM Foroud, WE Roberts: Root Resorption Associated with Orthodontic Force in Mice: Genetic Contributions. Eur J Orthod 28:13-19;2006 (Advance Access published on December 22, 2005). Selected by the Editorial Board of the European Journal of Orthodontics to receive the Beni Solow Award for the best publication in the Journal in 2006. 

Hartsfield JK Jr, WF Hohlt, WE Roberts: Orthodontic Treatment and Orthognathic Surgery in Patients with Osteogenesis Imperfecta. Semin Orthod 12:254-271;2006. 

Roberts WE, JA Roberts, BN Epker, DB Burr, JK Hartsfield Jr: Remodeling of Mineralized Tissues, Part I: The Frost Legacy. Semin Orthod 12:216-237;2006. 

Roberts WE, BN Epker, DB Burr, JK Hartsfield Jr, JA Roberts: Remodeling of Mineralized Tissues, Part II: Control and Pathophysiology. Semin Orthod 12: 238-253;2006. 

Abass SK, JK Hartsfield Jr: Genetic Studies In Root Resorption And Orthodontia. Biological Mechanisms of Tooth Eruption, Resorption, and Movement. eds. Z Davidovitch and J Mah, The Harvard Society for the Advancement of Orthodontics. Pages 39-46, 2006. 

Roberts WE, JK Hartsfield Jr, RA Al-Qawasmi, TR Katona: Physiologic interaction of root resorption, remodeling, tooth movement and ankylosis. Biological Mechanisms of Tooth Eruption, Resorption and Movement. eds. Z Davidovitch and J Mah, The Harvard Society for the Advancement of Orthodontics. Pages 191-198, 2006. 

Hartsfield JK Jr: Genetics and Orthodontics. Orthodontics Current Principles and Techniques, fourth edition. TM Graber, RL Vanarsdall, and KWL Vig, eds. Mosby, Inc. St. Louis, MO, 2005. 

McDonald RE, DR Avery, JK Hartsfield Jr: Acquired and Developmental Disturbances of the Teeth and Associated Oral Structures. Dentistry for the Child and Adolescent, eighth edition. RE McDonald, DR Avery, and JA Dean, eds. Mosby, Inc. St. Louis, MO. Pages 103-147, 2004. 

Hartsfield JK Jr, Bixler D: Clinical Genetics for the Dental Practitioner. Dentistry for the Child and Adolescent, eighth edition. RE McDonald, DR Avery, and JA Dean, eds. Mosby, Inc. St. Louis, MO. Pages 79-102, 2004. 

Pinskaya YB, T-J Hsieh, WE Roberts, JK Hartsfield Jr: Comprehensive clinical evaluation as an outcome assessment for a graduate orthodontics program. Am J Orthod Dentofacial Orthop 126:533-543;2004. 

Roberts WE, RA Al-Qawasmi, JK Hartsfield Jr, TR Katona TR. Biomechanics of root resorption. In: Orthodontics Year Book '04, Quintessence Publishing Company, Tokyo. Pages 84-90, 2004. 

Roberts WE, JK Hartsfield Jr: Bone Development and Function: Genetic and Environmental Mechanisms. Semin Orthod 10:100-122;2004. 

Hartsfield JK Jr, ET Everett, RA Al-Qawasmi: Genetic Factors in External Apical Root Resorption and Orthodontic Treatment. Crit Rev Oral Biol Med 15:115-122;2004. 

Deguchi T, T Takano-Yamamoto, R Kanomi, JK Hartsfield Jr, WE Roberts, LP Garetto: Miniature implants for orthodontic anchorage. J Dent Res 82:377-381;2003. 

Al-Qawasmi RA, JK Hartsfield Jr, ET Everett, LL Flury, L Liu, TM Foroud, JV Macri, WE Roberts: Genetic Linkage of Chromosome 18 with Root Resorption Associated with Orthodontic Treatment. J Dent Res 82:356-360;2003. 

Al-Qawasmi RA, JK Hartsfield Jr, ET Everett, LL Flury, L Liu, TM Foroud, JV Macri, WE Roberts: Genetic Predisposition to External Apical Root Resorption. Am J Orthod Dentofacial Orthop 123:242-252;2003. 

Toutain A, B Dessay, N Ronce, MI Ferrante, J Tranchemontagne, R Newbury-Ecob, C Wallgren-Pettersson, J Burn, J Kaplan, A Rossi, S Russo, I Walpole, JK Hartsfield, N Oyen, A Nemeth, P Bitoun, D Trump, C Moraine, B Franco: Refinement of the NHS locus on chromosome Xp22.13 and analysis of 5 candidate genes. Eur J Hum Genet 10:516-520;2002. 

Hartsfield JK Jr: Development of the vertical dimension: nature and nurture. Semin Orthod 8:113-119;2002. 

RE Ward, ES Moore, JK Hartsfield Jr: Morphometric characteristics of subjects with oral clefts and their relatives. Cleft Lip and Palate. From Origin to Treatment. DF Wyszynski, ed. Oxford University Press, Oxford. Pages 66-86, 2002. 

Hartsfield JK Jr and LP Garetto: Dental Care for Persons with OI. Public Information sheet for the Osteogenesis Imperfecta Foundation, Inc, 2002. 

Amador AG, PD Righi, S Radpour, ET Everett, E Weisberger, M Langer, GJ Eckert, AG Christen, S Campbell Jr, DJ Summerlin, N Reynolds, JK Hartsfield Jr: Polymorphisms of Xenobiotic Metabolizing Genes in Oropharyngeal Carcinoma. Oral Surgery, Oral Pathology, Oral Medicine, Oral Radiology and Endodontics 93:440-446;2002. 

Hartsfield JK Jr, TA Hickman, ET Everett, GM Shaw, EJ Lammer, RA Finnell: Analysis of the EPHX1 113 Polymorphism and GSTM1 Homozygous Null Polymorphism and Oral Clefting Associated with Maternal Smoking. Am J Med Genet 102:21-24;2001. 

Hartsfield JK Jr, ET Everett: The Ephx1d allele encoding an Arg338Cys substitution is associated with heat lability. Mamm Genome 11:915-918;2000. 

Everett ET, JK Hartsfield Jr: Mouse models for craniofacial anomalies. In Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. Davidovitch Z and Mah J, eds. Harvard Society for the Advancement of Orthodontics, Boston. Pages 287-298, 2000. 

RE McDonald, DR Avery, JK Hartsfield Jr: Acquired and Developmental Disturbances of the Teeth and Associated Oral Structures. Dentistry for the Child and Adolescent, seventh edition. RE McDonald and DR Avery, eds. Mosby, Inc. St. Louis, MO. Pages 105-150, 2000. 

Bixler D, JK Hartsfield Jr: Clinical Genetics for the Dental Practitioner. Dentistry for the Child and Adolescent, seventh edition. RE McDonald and DR Avery, eds. Mosby, Inc. St. Louis, MO. Pages 82-104, 2000. 

Everett ET, D Britto, RE Ward, JK Hartsfield Jr: A novel FGFR2 gene mutation in Crouzon syndrome associated with non-penetrance. Cleft Palate Craniofacial J 36:533-541;1999. 

Cook L, DD Weaver, JK Hartsfield Jr, GH Vance: Brief report: De Novo10q22 interstitial deletion. J Med Genet 36:71-72;1999. 

Hartsfield JK Jr, MJ Sutcliffe, ET Everett, C Hassett, C Omiecinsky, JA Saari: Assignment of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. Cytogenetics and Cell Genetics 83:44-45;1998. 

Cook L, JK Hartsfield Jr, GH Vance: Partners with reciprocal translocations: Genetic counseling for the "double translocation." Clin Genet 53:403-407;1998. 

Dean JA, JK Hartsfield Jr, JT Wright, TC Hart: Genetic linkage of dentin dysplasia type II to chromosome 4q. J Cranio Genet Dev Biol 17:172-177;1997. 

Roberts WE, JK Hartsfield Jr: Multidisciplinary management of congenital and acquired compensated malocclusions: Diagnosis, etiology and treatment planning. J Indiana Dent Asso 76(2):42-51;1997. 

Romie SS, JK Hartsfield Jr, MJ Sutcliffe, DP Dumont, BG Kousseff: Monosomy 6q1: Syndrome delineation. Am J Med Genet 62:105-108;1996. 

Hartsfield JK Jr, SA Benford, DR Hilbelink: Induction of microsomal epoxide hydrolase activity in inbred mice by chronic phenytoin exposure. Biochem Mol Med 56:144-151;1995. 

Hartsfield JK Jr, LB Holmes, JG Morel: Phenytoin embryopathy: Effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice. Biochem Mol Med 56:131-143;1995.

Mueller OT, JK Hartsfield Jr, MJA Amar, LA Gallardo, BG Kousseff: Fragile X syndrome: Discordant levels of CGG repeat mosaicism in two brothers. Am J Med Genet 60:302-306; 1995. 

Hartsfield JK Jr: Premature exfoliation of teeth in childhood and adolescence. Adv Pediatr 41:453-470;1994. 

Nolan MF, JK Hartsfield Jr, DM Witters, PJ Wason: Failure of transcutaneous electrical nerve stimulation in the conventional and burst modes to alter digital skin temperature. Arch Phys Med Rehabil 74:182-187;1993. 

Hartsfield JK Jr, BD Hall, AW Grix, BG Kousseff, JF Salazar, SMW Haufe: Pleiotropy in Coffin-Lowry syndrome: Sensorineural hearing deficit and premature tooth loss as early manifestations. Am J Med Genet 45:552-557;1993. 

Hartsfield JK Jr, M Lee, JG Morel, DR Hilbelink: Statistical Analysis of the Effect of Cadmium and Zinc on Hamster Teratogenesis. Biochem Med Metab Biol 48:159-173;1992. 

Mueller OT, JK Hartsfield Jr, LA Gallardo, YP Essig, KL Miller, PR Papenhausen, TA Tedesco: Lowe syndrome in a female with a balanced X:20 translocation: Mapping of the X chromosome breakpoint. Am J Hum Genet 49:804-810; 1991. 

Hartsfield JK Jr: Intestinal hypoperistalsis megacystis-microcolon type. Birth Defects Encyclopedia. ML Buyse, ed. Blackwell Scientific Publications, Inc. Cambridge, MA. Pages 978-979, 1990. 

Hartsfield JK Jr: Megacystis megaduodenum syndrome. Birth Defects Encyclopedia. ML Buyse, ed. Blackwell Scientific Publications, Inc. Cambridge, MA. Page 1115, 1990. 

Hartsfield JK Jr, RA Patel: Gingival fibromatosis-deafness, Jones type. Birth Defects Encyclopedia. ML Buyse, ed. Blackwell Scientific Publications, Inc. Cambridge, MA. Pages 777-778, 1990. 

Hartsfield JK Jr, BG Kousseff: Phenotypic overlap of Ehlers-Danlos syndrome types IV and VIII. Am J Med Genet 37:465-470;1990. 

Hartsfield JK Jr, LB Holmes: Comparison of two methods for linear measurement of ossified tissue in cleared mouse fetuses. J Craniofac Genet Dev Biol 8:345-350;1988. 

Hartsfield JK Jr, D Bixler, RH Hazen: Gingival fibromatosis with sensorineural hearing loss: an autosomal dominant trait. Am J Med Genet 22:623-627;1985. 

Hartsfield JK Jr, D Bixler, WE DeMyer: Hypertelorism associated with holoprosencephaly and ectrodactyly. J Clin Dysmorphol 2:27-31;1984. 

Bixler D, M Higgins, JK Hartsfield Jr: The Nance-Horan syndrome: a rare X-linked ocular-dental trait with expression in heterozygous females. Clin Genet 26:30-35;1984. 

Hartsfield JK Jr, D Bixler: Bilateral macrostomia in one of monozygotic twins. Oral Surg 57:648-51;1984.